您好，欢迎访问黑龙江省农业科学院 机构知识库！
黑龙江省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Sp1 is an important transcriptional regulation factor for forkhead box N1 in pig

文献类型： 外文期刊

作者： Zhang, Dong Jie 1 ; Wang, Liang 1 ; Li, Zhong Qiu 1 ; Fu, Bo 1 ; Yang, Guo Wei 1 ; Liu, Di 1 ;

作者机构： 1.Heilongjiang Acad Agr Sci, Inst Anim Husb, Harbin 150086, Heilongjiang, Peoples R China

关键词： pig; Foxn1 gene; transcriptional regulation; Sp1

期刊名称：JOURNAL OF GENETICS （ 影响因子：1.166； 五年影响因子：1.212 ）

ISSN： 0022-1333

年卷期： 2018 年 97 卷 1 期

页码：

收录情况： SCI

摘要： The transcription factor forkhead box N1 (Foxn1) plays an important role in the development and function of thymic epithelial cells (TECs) in vertebrates. However, the transcriptional regulation of Foxn1 is still unknown. A series of dual luciferase report vectors were constructed and their relative activities were also detected. The 5'-untranslated regions contains two cis-acting elements, Sp1 and GATA-1, as well as trans-acting elements between positions -332 to -438. Nevertheless, the relative activities of Foxn1 promoter were significantly increased in PK15 cells only when the Sp1 was overexpressed, suggesting that the Sp1 was the most important sequence for Foxn1 transcription activation in the pig. Regrettably, the exact trans-acting elements were not found.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：黑龙江省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台