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Adverse reproductive performance in zebrafish with increased bioconcentration of microcystin-LR in the presence of titanium dioxide nanoparticles

文献类型： 外文期刊

作者： Cheng, Houcheng 1 ; Yan, Wei 2 ; Wu, Qin 1 ; Lu, Juanli 1 ; Liu, Chunsheng 1 ; Hung, Tien-Chieh 3 ; Li, Guangyu 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

2.Hubei Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Wuhan 430064, Hubei, Peoples R China

3.Univ Calif Davis, Dept Biol & Agr Engn, Davis, CA 95616 USA

4.Hubei Prov Engn Lab Pond Aquaculture, Wuhan 430070, Hubei, Peoples R China

期刊名称：ENVIRONMENTAL SCIENCE-NANO （ 影响因子：8.131； 五年影响因子：8.3 ）

ISSN： 2051-8153

年卷期： 2018 年 5 卷 5 期

页码：

收录情况： SCI

摘要： The aim of the present study was to investigate the reproductive effects of microcystin-LR (MCLR) in the presence of titanium dioxide nanoparticles (n-TiO2). Five-month-old zebrafish were exposed to MCLR (0, 0.5, 4 and 32 mu g L-1) alone or combined with n-TiO2 (100 mu g L-1) for 21 days. The accumulation of both n-TiO2 and MCLR was observed in the fish liver, brain and gonad. Enhanced bioconcentration of MCLR was measured in coexposure groups. Joint exposure to both n-TiO2 and MCLR significantly reduced the fecundity of adult fish compared to the MCLR-only treatment. Histopathological examination revealed no obvious change in the morphology of the ovary and testis, while a significant decline of estradiol (E2) and testosterone (T) levels as well as disordered transcription patterns of genes along the hypothalamus-pituitary-gonadal (HPG) axis was observed. N-TiO2 may act as a carrier of MCLR and increase its concentration upon coming in contact with zebrafish, which exacerbated the reproductive endocrine dysfunction as a consequence.

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