Cytotoxic and Antibacterial Eremophilane Sesquiterpenes from the Marine-Derived Fungus Cochliobolus lunatus SCSI041401
文献类型： 外文期刊
作者： Fang, Wei 1 ; Wang, Jianjiao 2 ; Wang, Junfeng 2 ; Shi, Liqiao 1 ; Li, Kunlong 2 ; Lin, Xiuping 3 ; Min, Yong 1 ; Yang, B 1 ;
作者机构： 1.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Hubei, Peoples R China
2.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China
3.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）
ISSN： 0163-3864
年卷期： 2018 年 81 卷 6 期
页码：
收录情况： SCI
摘要： Three new eremophilane sesquiterpenes, dendryphiellins H-J (1-3), and three new phthalide natural products (4-6) were isolated from the marine-derived fungus Cochliobolus lunatus SCSI041401. Their structures including absolute configurations were determined by spectroscopic and calculated ECD analyses. Dendryphiellin I (2) showed cytotoxic and antibacterial activities against five cancer cell lines (IC50 1.4 to 4.3 mu M) and three bacterial species (MIC 1.5 to 13 mu g/mL), respectively. Dendryphiellin J (3), a rare naturally occurring aldoxime analogue, displayed cytotoxicities against ACHN and HepG-2 cells with IC50 values of 3.1 and 5.9 mu M, respectively. Further studies indicated that 3 induced apoptosis in ACHN cells in a dose- and time-dependent manner.
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