Cytotoxic and Antibacterial Eremophilane Sesquiterpenes from the Marine-Derived Fungus Cochliobolus lunatus SCSI041401
文献类型： 外文期刊
作者： Fang, Wei 1 ; Wang, Jianjiao 2 ; Wang, Junfeng 2 ; Shi, Liqiao 1 ; Li, Kunlong 2 ; Lin, Xiuping 3 ; Min, Yong 1 ; Yang, B 1 ;
作者机构： 1.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Hubei, Peoples R China
2.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China
3.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）
ISSN： 0163-3864
年卷期： 2018 年 81 卷 6 期
页码：
收录情况： SCI
摘要： Three new eremophilane sesquiterpenes, dendryphiellins H-J (1-3), and three new phthalide natural products (4-6) were isolated from the marine-derived fungus Cochliobolus lunatus SCSI041401. Their structures including absolute configurations were determined by spectroscopic and calculated ECD analyses. Dendryphiellin I (2) showed cytotoxic and antibacterial activities against five cancer cell lines (IC50 1.4 to 4.3 mu M) and three bacterial species (MIC 1.5 to 13 mu g/mL), respectively. Dendryphiellin J (3), a rare naturally occurring aldoxime analogue, displayed cytotoxicities against ACHN and HepG-2 cells with IC50 values of 3.1 and 5.9 mu M, respectively. Further studies indicated that 3 induced apoptosis in ACHN cells in a dose- and time-dependent manner.
- 相关文献
作者其他论文 更多>>
-
Genomic and Comparative Transcriptomic Analyses Reveal Key Genes Associated with the Biosynthesis Regulation of Okaramine B in Penicillium daleae NBP-49626
作者：Wang, Yueying;Chen, Ling;Fang, Wei;Zeng, Zhen;Wu, Zhaoyuan;Liu, Fang;Liu, Xiaoyan;Gong, Yan;Zhu, Lei;Wang, Kaimei
关键词：Okaramine B; yield improvement; Penicillium daleae; complete genome; transcriptome; novel regulators; tryptophan metabolism
-
Discovery of structural diversity guided steroidal thiazolidin-4-one derivatives as potential cytotoxic agents targeting CDK1
作者：Yang, Fei;Min, Yong;Li, Kui;Yang, Ziwen;Wang, Kaimei;Gong, Yan;Liu, Manli;Ke, Shaoyong;Yang, Fei;Yang, Ziwen;Liu, Changli
关键词：Steroidal thiazolidin-4-ones; Structural diversity; Antiproliferative activity; Enzyme inhibitors; Molecular docking
-
3-(Methylthio)Propionic Acid from Bacillus thuringiensis Berliner Exhibits High Nematicidal Activity against the Root Knot Nematode Meloidogyne incognita (Kofoid and White) Chitwood
作者：Chen, Ling;Wang, Yueying;Zhu, Lei;Min, Yong;Tian, Yuxi;Gong, Yan;Liu, Xiaoyan
关键词：Bacillus thuringiensis; volatile organic compounds; 3-(methylthio)propionic acid; Meloidogyne incognita; nematicidal activity; attraction
-
Substituted pyrazole derivatives as potential fungicidal agents
作者：Huang, Daye;Liu, Fang;Wen, Shaohua;Wang, Yueying;Fang, Wei;Zhang, Zhigang;Ke, Shaoyong
关键词：Pyrazole carboxamide; Hydrazone; Plant disease; Fungicidal activity
-
High-Quality Genome and Annotation Resource of Orange Pink Rot Pathogen Trichothecium roseum Strain YXFP-22015 Isolated from Hubei, China
作者：Zhu, Lei;Wu, Zhaoyuan;Fang, Wei;Wang, Yueying
关键词：annotation; fungi; high-quality genome; pink rot disease; RNA-seq; Trichothecium roseum
-
Bioactive Polyketides and Benzene Derivatives from Two Mangrove Sediment-Derived Fungi in the Beibu Gulf
作者：Peng, Bo;Cai, Jian;Li, Xinlong;Yang, Bin;Chen, Chunmei;Zhou, Xuefeng;Xiao, Zimin;Tao, Huaming;Liu, Manli;Fang, Wei;Huang, Yi-You
关键词：mangrove sediment-derived fungi; polyketide; stachylines; biological activity
-
Highly efficient construction of multi-substituted aminopyrazoles derivatives via iodine-mediated three-components reaction as potential anticancer agents
作者：Gao, Zilin;Liu, Manli;Shi, Liqiao;Zhang, Zhigang;Yang, Fei;Wang, Kaimei;Ke, Shaoyong;Gao, Zilin;Chen, Yu;Cao, Xiufang;Huang, Wenbo;Yang, Fei;Cao, Xiufang;Wang, Kaimei;Ke, Shaoyong
关键词：Aminipyrazole derivatives; three-component reaction; reaction mechanism; biological application; SARs; kinase inhibitor; molecular docking
