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Anti-inflammatory effects of newly synthesized a-galacto-oligosaccharides on dextran sulfate sodium-induced colitis in C57BL/6J mice

文献类型： 外文期刊

作者： Dai, Zhuqing 1 ; Feng, Simin 1 ; Liu, Anna 1 ; Wang, Hong 1 ; Zeng, Xiaoxiong 2 ; Yang, Chung S. 1 ;

作者机构： 1.Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Piscataway, NJ 08854 USA

2.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China

3.Zhejiang Univ Technol, Hangzhou 310014, Zhejiang, Peoples R China

4.Jiangsu Acad Agr Sci, Inst Farm Prod Proc, Nanjing 210014, Jiangsu, Peoples R China

关键词： Colitis; Anti-inflammatory; alpha-GOSg; Cyclooxygenase-2

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：6.475； 五年影响因子：6.508 ）

ISSN： 0963-9969

年卷期： 2018 年 109 卷

页码：

收录情况： SCI

摘要： alpha-Galacto-oligosaccharides have been reported to have beneficial health effects. The purpose of this study was to investigate the preventive effects of a newly synthesized a-galacto-oligosaccharide mixture (alpha-GOSg), as well as raffinose family oligosaccharides (RFOs), on dextran sulfate sodium (DSS)-induced colitis in mice. When administered in drinking water at 0.5% for 15 days, both alpha-GOSg and RFOs significantly decreased fecal hemoglobin content, partially prevented colon length shortening, reduced the severity of colon inflammation, and attenuated DSS-induced upregulation of cyclooxygenase-2. In addition, the activation of the inflammatory regulator nuclear factor-kappa B was slightly inhibited by alpha-GOSg. The results showed that the newly synthesized alpha-GOSg preparation has similar anti-inflammatory activities as RFOs in this colitis model. The anti-inflammatory activity of alpha-GOSg in humans remains to be investigated.

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