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Chemokine receptor antagonist block inflammation and therapy Japanese encephalitis virus infection in mouse model

文献类型： 外文期刊

作者： Liu, Ke 1 ; Xiao, Changguang 1 ; Wang, Feifei 2 ; Xiang, Xiao 1 ; Ou, Anni 1 ; Wei, Jianchao 1 ; Li, Beibei 1 ; Shao, Don 1 ;

作者机构： 1.Chinese Acad Agr Sci, Shanghai Vet Res Inst, 518 Ziyue Rd, Shanghai 200241, Peoples R China

2.Nanjing Agr Univ, Mol Virol & Comparat Med, Teaching Bldg Room 420&422, Nanjing 210095, Jiangsu, Peoples R China

3.Shanghai Acad Agr Sci, Shanghai 201106, Peoples R China

4.Chinese Acad Sci

关键词： Inflammation related genes; Chemokines; Japanese encephalitis virus

期刊名称：CYTOKINE （ 影响因子：3.861； 五年影响因子：4.257 ）

ISSN： 1043-4666

年卷期： 2018 年 110 卷

页码：

收录情况： SCI

摘要： Japanese encephalitis (JE) is a viral encephalitis disease caused by infection with the Japanese encephalitis virus (JEV). The virus can cross the blood-brain barrier and cause death or long-term sequela in infected humans or animals. In this study, we first investigated the distribution of JEV infection in brain and further analyzed the dynamic change in inflammation related genes, chemokines, as well as pathological characteristics. Results demonstrated that CCR2 and CCR5 antagonist could significantly inhibit the inflammation. The mice treated with CCR2 and CCR5 antagonists had a higher survival rate between 60% and 70%, respectively. In summary, our study thoroughly illustrated the characteristics of the dynamic change in inflammation related genes and chemokines induced by JEV infection. We further indicated that CCR5 and CCR2 are potential targets for treatment of JE.

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