Identification of Two Novel Single Nucleotide Polymorphyisms in the Promoter Region of the Pig AMP Deaminase 1 Gene Associated with Carcass Traits
文献类型： 外文期刊
作者： Wang, Linjie 1 ; Chao, Zhe 2 ; Wang, Yan 1 ;
作者机构： 1.Sichuan Agr Univ, Coll Anim Sci & Technol, Farm Anim Genet Resources Explorat & Innovat Key, Chengdu 611130, Sichuan, Peoples R China
2.Hainan Acad Agr Sci, Inst Anim Sci & Vet Med, Haikou, Hainan, Peoples R China
关键词： AMP deaminase; pig; promoter; SNP; carcass traits
期刊名称：DNA AND CELL BIOLOGY （ 影响因子：3.311； 五年影响因子：3.557 ）
ISSN： 1044-5498
年卷期： 2018 年 37 卷 11 期
页码：
收录情况： SCI
摘要： The AMP deaminase 1 (AMPD1) gene plays an important role in purine nucleotide interconversion and energy metabolism. In this study, two novel single nucleotide polymorphyisms (SNPs) (g.-626 G>A and g.-566A>G) were detected in the proximal promoter region of the AMPD1 gene. The Chinese indigenous pig breeds (Meishan and Tongcheng) had higher frequencies of the G and A alleles than Western meat-type breeds (Landrace and Large White) at the g.-626 G>A and g.-566A>G loci. The transcriptional activity of the AMPD1 promoter carrying the haplotype H1 (A(-626)G(-566)) was significantly (p<0.05) higher than that of the haplotype H2 (G(-626)A(-566)). In addition, pigs with the haplotype combination H1H1 had significantly (p<0.05) higher mRNA expression levels of the AMPD1 gene than those with haplotype combinations H1H2 and H2H2 in two different skeletal muscles. Association analyses revealed that the pigs with the haplotype combination H1H1 had significantly higher lean meat percentage values but lower average backfat thickness (ABT, cm), buttock fat thickness (cm), and thorax-waist fat thickness (cm) values than the pigs with the haplotype combinations H1H2 and H2H2. These findings demonstrate that the two novel SNPs in the promoter region of the AMPD1 gene have significant associations with pig fat deposition traits.
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