Self-assembly of natural protein and imidazole molecules on gold nanoparticles: Applications in wound healing against multi-drug resistant bacteria
文献类型： 外文期刊
作者： Lu, Bitao 1 ; Lu, Fei 1 ; Ran, Luoxiao 1 ; Yu, Kun 1 ; Xiao, Yang 3 ; Li, Zhiquan 3 ; Dai, Fangying 1 ; Wu, Dayang 1 ; Lan, 1 ;
作者机构： 1.Southwest Univ, Coll Text & Garments, Chongqing 400715, Peoples R China
2.Chongqing Engn Res Ctr Biomat Fiber & Modern Text, Chongqing 400715, Peoples R China
3.Guangdong Acad Agr Sci, Sericulture & Agrifood Res Inst, Guangzhou 510610, Guangdong, Peoples R China
关键词： Gold nanoparticles; 2-mercapto-1-methylimidazole; Chicken egg white proteins; Antibacterial activity; Wound dressing
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）
ISSN： 0141-8130
年卷期： 2018 年 119 卷
页码：
收录情况： SCI
摘要： Developing highly active and green antibacterial agents for pathogens, especially multidrug-resistant superbugs, is vital for solving the problem of serious antibiotic resistance. Herein, we report a unique system of gold nano particles coated with chicken egg white (CEW) and 2-mercapto-1-methylimidazole (MMT) as a novel antibacterial agent. The CEW was used to prepare the gold nanoparticles as a commercially available reducing and stabilizing agent, and then the MMT self-assembled on the surface of nanoparticles. The resulting Au@CEW/MMT was found to be a highly efficient antibacterial agent, and the activity is mainly attributed to the synergistic effects of MMT and Au@CEW in undermining the bacterial membrane. Meanwhile, the studies of antibacterial activities and biocompatibility of Au@CEW/MMT with different ratios of MMT conjugation to Au@CEW confirmed that Au@CEW/MMT3 (MMT:HAuCl4 = 1:50) can maintain a balance between antibacterial properties and biocompatibility. Furthermore, in an in-vivo study using the rabbit model, gauze loaded with Au@CEW/MMT3 can effectively accelerate the healing of wounds infected with methicillin-resistant S. aureus and promote the formation of collagen. Therefore, this work illustrated a promising material with broad-spectrum antibacterial activities for preclinical applications in treating wound infections. (C) 2018 Elsevier B.V. All rights reserved.
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