Identification of Host Molecules Involved in the Proliferation of Nucleopolyhedrovirus in Bombyx mori
文献类型： 外文期刊
作者： Xu, Jing 1 ; Xie, Xiaole 1 ; Ma, Qiuqin 1 ; Zhang, Lu 1 ; Li, Yu 1 ; Chen, Yin 1 ; Li, Kang 1 ; Xiao, Yang 5 ; Tettamanti, Gianluca 6 ; Xu, Hanhong 2 ; Tian, Ling 1 ;
作者机构： 1.South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangdong Prov Key Lab Agro Anim Genom & Mol Breed, Coll Anim Sci, Guangzhou 510642, Peoples R China
2.South China Agr Univ, State Key Lab Conservat & Utilizat Subtrop Agro Bi, Ministryof Educ, Key Lab Nat Pesticide & Chem Biol, Guangzhou 510642, Peoples R China
3.Shaoguan Univ, Henry Fok Sch Biol & Agr, Shaoguan 512005, Peoples R China
4.South China Normal Univ, Guangdong Prov Key Lab Insect Dev Biol & Appl Tech, Inst Insect Sci & Technol, Sch Life Sci, Guangzhou 510631, Peoples R China
5.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangzhou 510507, Peoples R China
6.Univ Insubria, Dept Biotechnol & Life Sci, I-21100 Varese, Italy
7.Univ Napoli Federico II, Interuniv Ctr Studieson Bioinspired Agro Environm, I-80055 Portici, Italy
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.895； 五年影响因子：6.048 ）
ISSN： 0021-8561
年卷期： 2022 年 70 卷 45 期
页码：
收录情况： SCI
摘要： The Bombyx mori nucleopolyhedrovirus (BmNPV), a foodborne infectious virus, is the pathogen causing nuclear polyhedrosis and high lethality in the silkworm. In this study, we characterized the molecules involved in BmNPV-silkworm interaction by RNA sequencing of the fat body isolated from the virus-susceptible strain P50. Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation showed that the upregulated differentially expressed genes (DEGs) were mainly involved in translation, signal transduction, folding, sorting, and degradation, as well as transport and catabolism, while the downregulated DEGs were predominantly enriched in the metabolism of carbohydrates, amino acids, and lipids at 72 h post BmNPV infection. Knockout of the upregulated somatomedin-B and thrombospondin type-1 domain-containing protein, probable allantoicase, trifunctional purine biosynthetic protein adenosine-3, and Psl and pyoverdine operon regulator inhibited the proliferation of BmNPV, while knockout of the downregulated clip domain serine protease 3 and carboxylesterase clade H, member 1 promoted it. The molecules herein identified provide a foundation for developing strategies and designing drugs against BmNPV. KEYWORDS: Bombyx mori, fat body, BmNPV, proliferation
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