Baculovirus protein kinase 1 activates AMPK-protein phosphatase 5 axis to hijack transcription factor EB for self-proliferation
文献类型： 外文期刊
作者： Pan, Jiasheng 1 ; Li, Xiaodong 3 ; Li, Rongsong 1 ; Chen, Yin 1 ; Memon, Fareed Uddin 1 ; Wu, Kun 1 ; Hu, Jianghao 1 ; Xie, Xiaole 1 ; Deng, Jianhao 1 ; Xu, Rongting 1 ; Li, Kang 4 ; Zhang, Chuanxi 7 ; Tian, Ling 1 ;
作者机构： 1.South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Coll Anim Sci, Guangzhou 510642, Peoples R China
2.South China Agr Univ, Coll Anim Sci, Guangdong Sericulture Engn Res Ctr, Guangzhou 510642, Peoples R China
3.Hechi Univ, Guangxi Collaborat Innovat Ctr Modern Sericulture, Guangxi Key Lab Sericulture Ecol & Appl Intelligen, Hechi 546300, Peoples R China
4.South China Normal Univ, Inst Insect Sci & Technol, Guangdong Prov Key Lab Insect Dev Biol & Appl Tech, Guangzhou 510631, Peoples R China
5.South China Normal Univ, Sch Life Sci, Guangzhou 510631, Peoples R China
6.South China Normal Univ, Guangmeiyuan R&D Ctr, Guangdong Prov Key Lab Insect Dev Biol & Appl Tech, Meizhou 514779, Peoples R China
7.Ningbo Univ, Inst Plant Virol, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Biotechnol Plant Protect,Minist Agr & Zhej, Ningbo 315211, Peoples R China
关键词： BmNPV protein kinase 1; B. mori serine/threonine protein phosphatase 5; BmTFEB; Dephosphorylation; Proliferation
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）
ISSN： 0141-8130
年卷期： 2025 年 298 卷
页码：
收录情况： SCI
摘要： Baculovirus causes lethal nuclear polyhedrosis in insects, whereas its regulatory mechanism on host transcription has not been fully illustrated. Herein, Bombyx mori nucleopolyhedrovirus (BmNPV) infection caused dephosphorylation and thus cytoplasmic-nucleo translocation of transcription factor EB (BmTFEB) by inhibiting Mechanistic target of rapamycin complex 1 (MTORC1), while upregulating Adenosine monophosphate-activated protein kinase (AMPK) signaling to promote self-proliferation through the rival protein kinase 1 in Bombyx mori. Significantly, B. mori serine/threonine protein phosphatase 5, which leads to dephosphorylation of BmTFEB and its nuclear importation, was identified to interact with BmTFEB dependent of BmAMPK. Dephosphorylation at S117 and S324 sites in BmTFEB were the essential phosphorylation sites for mediating the cytoplasmic-nucleo translocation after BmNPV infection. Notably, BmTFEB upregulated the expressions of a set of metabolism- related genes to facilitate BmNPV proliferation, and BmTFEB knockout partly rescued larval survival. This study sheds light on the subtle interaction between NPV and the host, and provides a potential target for the utilization or control of the pathogen.
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