您好，欢迎访问湖北省农业科学院 机构知识库！
湖北省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Parental transfer of titanium dioxide nanoparticle aggravated MCLR- induced developmental toxicity in zebrafish offspring

文献类型： 外文期刊

作者： Wu, Qin 1 ; Yan, Wei 2 ; Liu, Chunsheng 1 ; Hung, Tien-Chieh 3 ; Li, Guangyu 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

2.Hubei Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Wuhan 430064, Hubei, Peoples R China

3.Univ Calif Davis, Dept Biol & Agr Engn, Davis, CA 95616 USA

4.Hubei Prov Engn Lab Pond Aquaculture, Wuhan 430070, Hubei, Peoples R China

期刊名称：ENVIRONMENTAL SCIENCE-NANO （ 影响因子：8.131； 五年影响因子：8.3 ）

ISSN： 2051-8153

年卷期： 2018 年 5 卷 12 期

页码：

收录情况： SCI

摘要： This work focuses on the transgenerational effects of titanium dioxide nanoparticles (n-TiO2) and microcystin-LR (MCLR) on the development of F1 zebrafish offspring. Wild-type adult zebrafish (4 months old) were exposed to various MCLR concentrations (0, 0.5, 4, and 32 g L-1) with and without n-TiO2 (100 g L-1) for 45 days. F1 zebrafish embryos from the above-mentioned parents were collected and cultured in clean water for 120 hours post-fertilization (hpf). Our results showed that n-TiO2 could potentially be transferred from parents to offspring, which further led to the increase in the accumulation of MCLR content in F1 zebrafish embryos. Hypoactivity and indistinct retinal layers in F1 larvae were observed, and the presence of n-TiO2 intensified these adverse effects in co-exposure groups. The parental transfer of MCLR and n-TiO2 further increased the formation of reactive oxygen species (ROS) in F1 larvae, which contributed to more apoptotic cells in and around the eyes of F1 larvae. Furthermore, we detected altered gene expression (p53, Bax, Bid, Bcl-2, puma, and Apaf-1), protein expression (P53, Bax, Bcl-2, and cytochrome c) and enzyme activities (caspase-3, caspase-8, and caspase-9), indicating that parental transfer of n-TiO2 could aggravate MCLR-induced apoptosis in F1 offspring through the mitochondria-mediated apoptosis pathway. In summary, this research studied the bioaccumulation, parental transfer, and developmental toxicity of MCLR and n-TiO2 to examine their interactions, revealing that the health risks of co-exposure should not be ignored.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：湖北省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台