文献类型： 外文期刊
作者： Xue, Tao 1 ; Li, Jizong 1 ; Liu, Chuanmin 2 ;
作者机构： 1.Linyi Univ, Sch Pharm, Linyi 276000, Peoples R China
2.Jiangsu Acad Agr Sci, Key Lab Vet Biol Engn & Technol, Inst Vet Med, Key Lab Vet Diag,Minist Agr, Nanjing 210014, Jiangsu, Peoples R China
关键词： Nitric oxide; Porcine circovirus type 2; In vitro
期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.741； 五年影响因子：2.955 ）
ISSN： 1746-6148
年卷期： 2019 年 15 卷
页码：
收录情况： SCI
摘要： Background: Porcine circovirus type 2 (PCV2) is the causal agent of postweaning multisystemic wasting syndrome (PMWS), causing large economical losses of the global swine industry. Nitric oxide (NO), as an important signaling molecule, has antiviral activity on some viruses. To date, there is little information on the role of NO during PCV2 infection. Results: We used indirect fluorescence assay (IFA), TCID50, real-time RT-qPCR and western blot assay to reveal the role of NO in restricting PCV2 replication. PCV2 replication was inhibited by a form of NO, NO center dot, whereas PCV2 was not susceptible to another form of NO, NO+. Conclusion: Our findings indicate that the form of NO center dot has a potential role in the fight against PCV2 infection.
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