您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Toxicokinetics and toxic effects of a Chinese PFOS alternative F-53B in adult it zebrafish

文献类型： 外文期刊

作者： Wu, Yongming 1 ; Deng, Mi 1 ; Jin, Yuanxiang 2 ; Liu, Xin 3 ; Mai, Zhaohuan 4 ; You, Hailin 1 ; Mu, Xiyan 5 ; He, Xiaoli; 1 ;

作者机构： 1.Jiangxi Acad Sci, Res Inst Poyang Lake, Nanchang 330012, Jiangxi, Peoples R China

2.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310032, Zhejiang, Peoples R China

3.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330029, Jiangxi, Peoples R China

4.Jiangxi Acad Sci, Inst Energy Convers, Nanchang 330012, Jiangxi, Peoples R China

5.Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing 100141, Peoples R China

6.Nanchang Univ, Coll Food Sci & Technol, Nanchang 330029, Jiangxi, Peoples R China

7.Univ Ottawa, Dept Biol, Ottawa, ON K1N 6N5, Canada

关键词： F-53B; Toxicokinetics; Toxic effects; zebrafish

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）

ISSN： 0147-6513

年卷期： 2019 年 171 卷

页码：

收录情况： SCI

摘要： 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), a Chinese PFOS alternative, has recently been identified in river water, sewage sludge, wildlife and humans, causing great concerns about its potential toxic effects. Here, we report the first investigation of the toxicokinetics and oxidative stress of F-53B in adult zebrafish. Adult male and female zebrafish were exposed to 10 and 100 mu g/L of F-53B for 7 days followed by a 5-d depuration period to examine bioaccumulation, distribution, and depuration of F-53B in fish. The results showed that F-53B was readily accumulated in fish tissues with log BCF values of 2.36-3.65, but was eliminated slowly (t(1/2) = 152.4-358.5 h). F-53B accumulation was greater in males than in females and the concentration in tissues decreased in the following order: gonad approximate to liver >> gill >> brain in females and liver approximate to gill >> gonad >> brain in males, showing sex- and tissue-specific accumulation of F-538 in fish. After chronic exposure to F-538 for 28 days, a significant dose-dependent increase in histopathological changes in the liver were mainly manifested by vacuolation. Furthermore, F-53B also significantly reduced the enzyme activity (or content) of most of the measured oxidative stress-related markers (e.g., SOD, CAT and MDA) except for an increase in GSH-Px activity, indicating that oxidative stress was induced in zebrafish after treatment with F-53B. The results of this study provide important information on the toxicokinetics and toxic effects of F-53B, which will contribute to the ecological risk assessments of F-53B released into surface waters.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台