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JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia

文献类型： 外文期刊

作者： Mansour, Marc R. 1 ; He, Shuning 2 ; Li, Zhaodong 2 ; Lobbardi, Riadh 3 ; Abraham, Brian J. 5 ; Hug, Clemens 2 ; Rahma 1 ;

作者机构： 1.UCL, Dept Haematol, Canc Inst, London, England

2.Harvard Med Sch, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

3.Massachusetts Gen Hosp, Mol Pathol & Canc Ctr, Boston, MA 02114 USA

4.Harvard Univ, Harvard Stem Cell Inst, Stem Cell & Regenerat Biol Dept, Cambridge, MA 02138 USA

5.Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA

6.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin, Heilongjiang, Peoples R China

7.Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA

8.Harvard Med Sch, Boston Childrens Hosp, Stem Cell Program, Boston, MA USA

9.Harvard Med Sch, Boston Childrens Hosp, Div Hematol Oncol, Boston, MA USA

10.Harvard Med Sch, Howard Hughes Med Inst, Dana Farber Canc Inst, Boston, MA USA

11.Leiden Univ, Med Ctr, Dept Immunohematol, Leiden, Netherlands

12.Natl Univ Singapore, Canc Sci Inst Singapore, Singapore, Singapore

13.Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore

14.MIT, Dept Biol, Cambridge, MA USA

期刊名称：JOURNAL OF EXPERIMENTAL MEDICINE （ 影响因子：14.307； 五年影响因子：14.851 ）

ISSN： 0022-1007

年卷期： 2018 年 215 卷 7 期

页码：

收录情况： SCI

摘要： A substantial subset of patients with T cell acute lymphoblastic leukemia (T-ALL) develops resistance to steroids and succumbs to their disease. JDP2 encodes a bZIP protein that has been implicated as a T-ALL oncogene from insertional mutagenesis studies in mice, but its role in human T-ALL pathogenesis has remained obscure. Here we show that JDP2 is aberrantly expressed in a subset of T-ALL patients and is associated with poor survival. JDP2 is required for T-ALL cell survival, as its depletion by short hairpin RNA knockdown leads to apoptosis. Mechanistically, JDP2 regulates prosurvival signaling through direct transcriptional regulation of MCL1. Furthermore, JDP2 is one of few oncogenes capable of initiating T-ALL in transgenic zebrafish. Notably, thymocytes from rag2:jdp2 transgenic zebrafish express high levels of mcl1 and demonstrate resistance to steroids in vivo. These studies establish JDP2 as a novel oncogene in high-risk T-ALL and implicate overexpression of MCL1 as a mechanism of steroid resistance in JDP2-overexpressing cells.

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