Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399
文献类型： 外文期刊
作者： Cong, Ziwen 1 ; Huang, Xiaolong 2 ; Liu, Yunhao 1 ; Liu, Yuxuan 1 ; Wang, Pei 3 ; Liao, Shengrong 1 ; Yang, Bin 1 ; Zhou, 1 ;
作者机构： 1.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Guangdong, Peoples R China
2.Hainan Univ, Inst Trop Agr & Forestry, Haikou 570228, Hainan, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China
期刊名称：JOURNAL OF ANTIBIOTICS （ 影响因子：2.649； 五年影响因子：2.772 ）
ISSN： 0021-8820
年卷期： 2019 年 72 卷 1 期
页码：
收录情况： SCI
摘要： Aranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (3-6), and two known tirandamycin derivatives (7 and 8). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2, 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 mu M, respectively. Besides, compounds 3, 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC(50 )values of 22.0 +/- 0.20, 1.80 +/- 0.01 and 12.1 +/- 0.07 mu M, respectively.
- 相关文献
作者其他论文 更多>>
-
Leveraging a phased pangenome for haplotype design of hybrid potato
作者：Cheng, Lin;Wang, Nan;Bao, Zhigui;Yang, Yuting;Wang, Pei;Zhang, Zhiyang;Tang, Die;Zhang, Pingxian;Wu, Yaoyao;Zhou, Yao;Zheng, Yi;Hu, Yong;Lian, Qun;Ma, Zhaoxu;Zhang, Chunzhi;Zhou, Yongfeng;Huang, Sanwen;Cheng, Lin;Lassois, Ludivine;Wang, Nan;Zhou, Yongfeng;Huang, Sanwen;Bao, Zhigui;Zhou, Qian;Guarracino, Andrea;Garrison, Erik;Tang, Die;Wu, Yaoyao;Zhou, Yao;Lucas, William J.;Stein, Nils;Stein, Nils;Staedler, Thomas;Staedler, Thomas
关键词：
-
Kitasatospora hibisci sp. nov., a novel actinomycete with antimicrobial potential isolated from rhizosphere soil of Hibiscus tiliaceus in Guangxi
作者：Xiao, Jinlan;Luo, Shenhao;Lu, Shiqi;Hong, Zhiwei;Huang, Xiaolong;Lin, Yongrui;Zhou, Shuangqing;Wang, Jiyang;Guo, Zhikai;Guo, Zhikai
关键词：antimicrobial potential; Hibiscus tiliaceus; Kitasatospora hibisci sp. nov.; polyphasic taxonomy
-
On the Study of Joint YOLOv5-DeepSort Detection and Tracking Algorithm for Rhynchophorus ferrugineus
作者：Wu, Shuai;Wang, Jianping;Chen, Danyang;Lu, Huimin;Wu, Shuai;Wei, Wei;Ji, Xiangchuan;Yang, Bin;Liu, Li
关键词：Red Palm Weevil; YOLOv5; joint YOLOv5-DeepSort; target tracking
-
Pan-genome and haplotype map of cassava cultivars and wild ancestors provide insights into its adaptive evolution and domestication
作者：Xia, Zhiqiang;Zhou, Xincheng;Jiang, Sirong;Chen, Fei;Zou, Meiling;Xu, Liangye;Guo, Xin;Wang, Shujuan;Li, Mengtao;Liu, Shisheng;Bao, Yuting;Zhang, Chenji;Xiao, Jianjia;Guo, Fengguang;Shen, Xu;Li, Haozheng;Zhang, Huaifang;He, Shuang;Wan, Yinglang;Chen, Yinhua;Huang, Dongyi;Li, Bin;Peng, Ming;Chen, Xin;Wang, Wenquan;Du, Zhenglin;Chen, Meili;Zhao, Wenming;Xiao, Jingfa;Du, Zhenglin;Chen, Meili;Zhao, Wenming;Xiao, Jingfa;Zhou, Xincheng;Wang, Haiyan;Lu, Cheng;Peng, Ming;Chen, Xin;Zhu, Tingting;Wang, Le;Luo, Ming-Cheng;Qiao, Fei;Li, Kaimian;Carvalho, Luiz;Lopez-Lavalle, Luis Augusto Becerra;Zhang, Xiaofei;Ceballos, Hernan;Wang, Zhenyu;Li, Yuanchao;Zhao, Long;Yan, Huabing;Qin, Xiaochun;Ma, Ling;Zhang, Weixiong;Moller, Birger Lindberg
关键词：genome; pan-genome; structural variations; selective sweeping; evolution and domestication; cassava
-
Self-healing modification of bio-based polyurethane coated fertilizers with aromatic disulfide compounds to enhance the controlled release of nitrogen
作者：Wang, Chao;Li, Hong;Shen, Yu;Du, Liqing;Yang, Ziming;He, Zuyu;Liu, Yunhao;Zhou, Chuang;Li, Puwang;Wang, Chao;Du, Liqing;He, Zuyu;Li, Puwang;Li, Hong;Shen, Yu
关键词：Self-healing; Bio-based polyurethane; Coated fertilizers; Controlled release; Aromatic disulfide
-
Bi-2-(2-phenethyl)chromone derivatives from agarwood of Aquilaria filaria in the Philippines
作者：Mei, Wei-Li;Dai, Hao-Fu;Yang, Hong -Run;Wang, Hao;Wang, Pei;Liu, Fang-Zheng;Chai, Hong-Xing;Cai, Cai-Hong;Yang, Li;Yuan, Jing-Zhe;Mei, Wei-Li;Dai, Hao-Fu;Yang, Hong -Run;Liu, Fang-Zheng;Chai, Hong-Xing;Jiang, Bei;Dai, Hao-Fu
关键词：Aquilaria filaria; Thymelaeaceae; 2-(2-Phenethyl)chromone dimers; Anti-inflammatory activity; Philippines
-
Homoerythrina-type alkaloids with neuroprotective activity from the branches of Cephalotaxus hainanensis Li
作者：Yan, Hao;Zhou, Shuang-Qing;Yan, Hao;Wang, Hao;Chen, Peng-Wei;Yang, Li;Chen, Hui -Qin;Wu, Fei;Wang, Pei;Dai, Hao-Fu;Mei, Wen-Li;Huang, Xiao-Long
关键词：Cephalotaxus hainanensis Li; Homoerythrina-type alkaloid; Neuroprotective activity
