Homoerythrina-type alkaloids with neuroprotective activity from the branches of Cephalotaxus hainanensis Li
文献类型： 外文期刊
作者： Yan, Hao 1 ; Wang, Hao 2 ; Chen, Peng-Wei 2 ; Yang, Li 2 ; Chen, Hui -Qin 2 ; Wu, Fei 2 ; Wang, Pei 2 ; Dai, Hao-Fu 2 ; Huang, Xiao-Long 3 ; Zhou, Shuang-Qing 1 ; Mei, Wen-Li 2 ;
作者机构： 1.Guilin Med Univ, Sch Pharm, Dept Pharmacognosy, Guilin 541199, Guangxi, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China
3.Hainan Univ, Sch Life Sci, Haikou 570228, Peoples R China
关键词： Cephalotaxus hainanensis Li; Homoerythrina-type alkaloid; Neuroprotective activity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.7； 五年影响因子：1.8 ）
ISSN： 1874-3900
年卷期： 2024 年 59 卷
页码：
收录情况： SCI
摘要： Lucidinine 13-N-oxide (1), one previously unreported homoerythrina N-oxide type alkaloid, and three known homoerythrina-type alkaloids (2-4) were isolated and elucidated from Cephalotaxus hainanensis Li. The structure of 1 were elucidated by extensive analysis of HRESIMS, 1D and 2D NMR data. The structures of three known alkaloids were elucidated by comparison with known compounds. The absolute configuration of 1 was estab-lished on the basis of experimental and computed ECD. All compounds was evaluated for neuroprotective ac-tivity against H2O2-induced apoptosis in human neuroblastoma SH-SY5Y cells. Lucidinine 13-N-oxide (1) significantly improved cell vitality of SH-SY5Y cells to 82.90 +/- 2.14% at concentration of 80 mu M.
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