Homoerythrina-type alkaloids with neuroprotective activity from the branches of Cephalotaxus hainanensis Li
文献类型： 外文期刊
作者： Yan, Hao 1 ; Wang, Hao 2 ; Chen, Peng-Wei 2 ; Yang, Li 2 ; Chen, Hui -Qin 2 ; Wu, Fei 2 ; Wang, Pei 2 ; Dai, Hao-Fu 2 ; Huang, Xiao-Long 3 ; Zhou, Shuang-Qing 1 ; Mei, Wen-Li 2 ;
作者机构： 1.Guilin Med Univ, Sch Pharm, Dept Pharmacognosy, Guilin 541199, Guangxi, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China
3.Hainan Univ, Sch Life Sci, Haikou 570228, Peoples R China
关键词： Cephalotaxus hainanensis Li; Homoerythrina-type alkaloid; Neuroprotective activity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.7； 五年影响因子：1.8 ）
ISSN： 1874-3900
年卷期： 2024 年 59 卷
页码：
收录情况： SCI
摘要： Lucidinine 13-N-oxide (1), one previously unreported homoerythrina N-oxide type alkaloid, and three known homoerythrina-type alkaloids (2-4) were isolated and elucidated from Cephalotaxus hainanensis Li. The structure of 1 were elucidated by extensive analysis of HRESIMS, 1D and 2D NMR data. The structures of three known alkaloids were elucidated by comparison with known compounds. The absolute configuration of 1 was estab-lished on the basis of experimental and computed ECD. All compounds was evaluated for neuroprotective ac-tivity against H2O2-induced apoptosis in human neuroblastoma SH-SY5Y cells. Lucidinine 13-N-oxide (1) significantly improved cell vitality of SH-SY5Y cells to 82.90 +/- 2.14% at concentration of 80 mu M.
- 相关文献
作者其他论文 更多>>
-
Leveraging a phased pangenome for haplotype design of hybrid potato
作者：Cheng, Lin;Wang, Nan;Bao, Zhigui;Yang, Yuting;Wang, Pei;Zhang, Zhiyang;Tang, Die;Zhang, Pingxian;Wu, Yaoyao;Zhou, Yao;Zheng, Yi;Hu, Yong;Lian, Qun;Ma, Zhaoxu;Zhang, Chunzhi;Zhou, Yongfeng;Huang, Sanwen;Cheng, Lin;Lassois, Ludivine;Wang, Nan;Zhou, Yongfeng;Huang, Sanwen;Bao, Zhigui;Zhou, Qian;Guarracino, Andrea;Garrison, Erik;Tang, Die;Wu, Yaoyao;Zhou, Yao;Lucas, William J.;Stein, Nils;Stein, Nils;Staedler, Thomas;Staedler, Thomas
关键词：
-
New Isocoumarins from an Endophytic Fungal Strain Diaporthe arengae M2 and their Antibacterial Activities
作者：Liu, De-Sui;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Liu, De-Sui;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Liu, De-Sui;Zhang, Jun-Feng;Wu, You-Gen
关键词：Endophytic fungi;
Diaporthe sp.; Isocoumarin derivatives; Antibacterial activity -
Identification of targets and comparative study of administration methods for the lipid-lowering effects of fucoidan from Saccharina japonica
作者：Chen, Pengwei;Wang, Hao;Chen, Huiqin;Dai, Haofu;Hao, Li;Li, Quancai;Zhang, Miao;Jiang, Hongfei;Zhang, Renshuai;Jia, Ang
关键词：Fucoidan; Lipid-lowering activity; Dietary supplementation; Intestinal target; Gut microbiota
-
Comprehensive analysis of morphology, transcriptomics, and metabolomics of banana (Musa spp.) molecular mechanisms related to plant height
作者：Wei, Junya;Cheng, Shimin;Huang, Lina;Wei, Shouxing;Liu, Guoyin;Sun, Mingzhen;Wang, Hao;Liu, Debing;Yang, Ping
关键词：banana; metabolomics; transcriptomics; hormones; height
-
2-(2-Phenylethyl)chromone-Sesquiterpene Hybrids from Agarwood of Aquilaria sinensis: Characterization and Biological Activity Evaluation
作者：Xu, Guan-Hua;Liu, Shou-Bai;Xu, Guan-Hua;Wang, Ya-Li;Wang, Hao;Chen, Hui-Qin;Dong, Wen-Hua;Huang, Sheng-Zhuo;Cai, Cai-Hong;Yuan, Jing-Zhe;Mei, Wen-Li;Dai, Hao-Fu
关键词：Hainan agarwood; 2-(2-phenylethyl)chromone-sesquiterpene hybrids; structure elucidation; anti-inflammatory activity; neuroprotective activity; cytotoxic activity
-
Three new dimeric 2-(2-phenethyl)chromones from the agarwood of Aquilaria malaccensis
作者：Yan, Xian-Yun;Liang, Lin-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu
关键词：Agarwood; Aquilaria malaccensis; 2-(2-phenethyl)chromone dimers; Anti-inflammatory activity
-
Comprehensive investigation of the C2H2-type zinc finger protein transcription factor family in Aquilaria sinensis reveals the involvement of AsZFP9 in sesquiterpene biosynthesis
作者：Li, Yuji;Guo, Dong;Wang, Hao;Wang, Ying;Peng, Shiqing;Dai, Haofu;Mei, Wenli;Zhu, Jiahong;Guo, Dong;Dai, Haofu;Zhu, Jiahong;Li, Yuji;Wang, Hao;Peng, Shiqing;Dai, Haofu;Mei, Wenli
关键词：Aquilaria sinensis; Zinc finger protein; Agarwood; Sesquiterpene biosynthesis
