Bi-2-(2-phenethyl)chromone derivatives from agarwood of Aquilaria filaria in the Philippines
文献类型： 外文期刊
作者： Yang, Hong -Run 2 ; Wang, Hao 2 ; Wang, Pei 2 ; Liu, Fang-Zheng 2 ; Chai, Hong-Xing 2 ; Cai, Cai-Hong 2 ; Yang, Li 2 ; Yuan, Jing-Zhe 2 ; Jiang, Bei 3 ; Mei, Wei-Li 1 ; Dai, Hao-Fu 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China
2.Int Joint Res Ctr Agarwood, Haikou 571101, Peoples R China
3.Yunnan Key Lab Screening & Res Antipathogen Plant, Dali 671000, Peoples R China
关键词： Aquilaria filaria; Thymelaeaceae; 2-(2-Phenethyl)chromone dimers; Anti-inflammatory activity; Philippines
期刊名称：PHYTOCHEMISTRY （ 影响因子：3.8； 五年影响因子：4.0 ）
ISSN： 0031-9422
年卷期： 2024 年 222 卷
页码：
收录情况： SCI
摘要： Twelve undescribed 2-(2-phenethyl)chromone dimers ( 1 - 12 ) were isolated from EtOAc extract of agarwood originating from Aquilaria filaria in the Philippines, guided by a UHPLC-MS analysis. Their structures were elucidated by 1D NMR, 2D NMR, and HR-ESI-MS spectra. The absolute configuration of 2-(2-phenylethyl) chromone dimers was determined by single-crystal X-ray diffraction analysis and comparison of the experimental and calculated ECD spectra. Compounds 1 , 2 , 5 and 9 - 12 exhibited potent to moderate anti-inflammatory activity with IC 50 values in the range of 22.43 +/- 0.86 to 53.88 +/- 4.06 mu M.
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