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Diverse ansamycin derivatives from the marine-derived Streptomyces sp. ZYX-F-97 and their antibacterial activities

文献类型： 外文期刊

作者： Yi, Ke-Xin 1 ; Xie, Qing-Yi 2 ; Ma, Qing-Yun 2 ; Yang, Li 2 ; Dai, Hao-Fu 2 ; Zhao, You-Xing 2 ; Hao, Yu-E 1 ;

作者机构： 1.Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang 421001, Hunan, Peoples R China

2.Inst Trop Biosci & Biotechnol, Chinese Acad Trop Agr Sci, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou 571101, Peoples R China

3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China

关键词： Marine-derived actinomycetes; Ansamycin derivatives; Antibacterial activity; Streptomyces sp.

期刊名称：FITOTERAPIA （ 影响因子：3.4； 五年影响因子：3.3 ）

ISSN： 0367-326X

年卷期： 2024 年 173 卷

页码：

收录情况： SCI

摘要： Four new ansamycin derivatives, named 1,19-epithio-geldanamycin A (1), 17-demethoxylherbimycin H (2), herbimycin M (3), and seco-geldanamycin B (4), together with eight known ansamycin analogues (5-12) were isolated from the solid fermentation of marine-derived actinomycete Streptomyces sp. ZYX-F-97. The structures of new compounds were elucidated by extensive spectroscopic analysis as well as nuclear magnetic resonance (NMR) and electronic circular dichroism (ECD) calculations. All the compounds were assayed for their antibacterial activity. Among them, compounds 4, 8, and 12 exhibited remarkable inhibition against Listeria monocytogenes with minimum inhibitory concentrations (MIC) values ranging from 8 mu g & sdot;mL- 1 to 64 mu g & sdot;mL- 1, and displayed moderate inhibition against methicillin-resistant Staphylococcus aureus (MRSA) with MIC value of 64 mu g & sdot;mL- 1. Compounds 4, 8, 9, and 12 showed moderate inhibition activities against both Staphylococcus aureus and Bacillus subtilis with MIC values ranging from 32 mu g & sdot;mL- 1 to 128 mu g & sdot;mL- 1.

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