Two unprecedented 2-(2-phenethyl)chromone dimers from red soil agarwood of Aquilaria crassna
文献类型： 外文期刊
作者： Chai, Hong-Xing 1 ; Wang, Hao 2 ; Zeng, Jun 2 ; Dong, Wen-Hua 2 ; Mei, Wen-Li 2 ; Jiang, Bei 1 ; Li, Wei 2 ; Dai, Hao-Fu 1 ;
作者机构： 1.Dali Univ, Coll Pharm, Dali 671003, Peoples R China
2.Inst Trop Biosci & Biotechnol, Chinese Acad Trop Agr Sci, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China
3.Int Joint Res Ctr Agarwood, Haikou 571101, Peoples R China
关键词： Aquilaria crassna; Red soil agarwood; 2-(2-Phenylethyl)chromone dimers; Anti-inflammatory activity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.7； 五年影响因子：1.8 ）
ISSN： 1874-3900
年卷期： 2024 年 59 卷
页码：
收录情况： SCI
摘要： Two unprecedented 2-(2-phenethyl)chromone dimers, aquicrassones A and B (1 and 2), were isolated by HPLCMS guided method from the ethanol extract of red soil agarwood originating from Aquilaria crassna in Vietnam. Their structures were unambiguously elucidated by analysis of HR-ESI-MS, 1D and 2D NMR, CD data and by comparison with literature data. Compounds 1 and 2 were evaluated for their inhibition effect on nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells. Compound 2 displayed anti-inflammatory activity with an IC50 value of 20.36 +/- 0.41 mu M.
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