Two unprecedented neuroprotective 2-(2-phenylethyl)chromone derivatives from cultivated "Qi-Nan" agarwood of Aquilaria sinensis
文献类型： 外文期刊
作者： Zhang, Lin 1 ; Yang, Li 1 ; Li, Wei 1 ; Chen, Hui-Qin 1 ; Yuan, Jing-Zhe 1 ; Cai, Cai-Hong 1 ; Li, Zhen-Yu 2 ; Mei, Wen-Li 1 ; Dai, Hao-Fu 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Int Joint Res Ctr Agarwood, Hainan Engn Res Ctr Agarwood,Natl Key Lab Trop Cro, Haikou 571101, Peoples R China
2.Shanxi Univ, Modern Res Ctr Tradit Chinese Med, Key Lab Chem Biol & Mol Engn, Minist Educ, Taiyuan 030006, Peoples R China
关键词： Cultivated "Qi-Nan" agarwood; Aquilaria sinensis; 2-(2-phenylethyl)chromone; Neuroprotective activity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.7； 五年影响因子：1.8 ）
ISSN： 1874-3900
年卷期： 2024 年 60 卷
页码：
收录情况： SCI
摘要： Two unprecedented 2-(2-phenylethyl)chromone derivatives, (R)-2-[2-hydroxy-2-(3-hydroxy-4-methoxyphenyl) ethyl]chromone (1) and (R)-1-hydroxy-5-(4-hydroxyphenyl)-1-phenylpentane-3-one (2), with one known compound were isolated from cultivated "Qi-Nan" agarwood of Aquilaria sinensis. Their structures were elucidated by analysis of 1D and 2D NMR as well as HRESIMS. TDDFT-ECD calculation was used to determine the absolute configuration. At 50 mu M, compounds 1 and 3 exhibited significant neuroprotective effect, enhancing the cell vitality of human neuroblastoma SH-SY5Y cells induced by H2O2 to 73.24 +/- 0.43% and 74.71 +/- 5.24%, respectively.
- 相关文献
作者其他论文 更多>>
-
New Isocoumarins from an Endophytic Fungal Strain Diaporthe arengae M2 and their Antibacterial Activities
作者：Liu, De-Sui;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Liu, De-Sui;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Liu, De-Sui;Zhang, Jun-Feng;Wu, You-Gen
关键词：Endophytic fungi;
Diaporthe sp.; Isocoumarin derivatives; Antibacterial activity -
EGDB: A comprehensive multi-omics database for energy grasses and the epigenomic atlas of pearl millet
作者：Luo, Lin;Qu, Qi;Zhang, Lin;Jiang, Dingkun;Zhu, Wenjun;Lu, Guodong;Zhu, Fangjie;Xiao, Jiajing;Lin, Dongmei;Chen, Hao;Luo, Yuan;Chen, Jiaming;Lin, Hui;Shao, Ensi;Lin, Zhanxi;Li, Jinhui;Lu, Peitao;Yan, Haidong;Jin, Yarong;Huang, Linkai;Xun, Lulu
关键词：
-
2-(2-Phenylethyl)chromone-Sesquiterpene Hybrids from Agarwood of Aquilaria sinensis: Characterization and Biological Activity Evaluation
作者：Xu, Guan-Hua;Liu, Shou-Bai;Xu, Guan-Hua;Wang, Ya-Li;Wang, Hao;Chen, Hui-Qin;Dong, Wen-Hua;Huang, Sheng-Zhuo;Cai, Cai-Hong;Yuan, Jing-Zhe;Mei, Wen-Li;Dai, Hao-Fu
关键词：Hainan agarwood; 2-(2-phenylethyl)chromone-sesquiterpene hybrids; structure elucidation; anti-inflammatory activity; neuroprotective activity; cytotoxic activity
-
Three new dimeric 2-(2-phenethyl)chromones from the agarwood of Aquilaria malaccensis
作者：Yan, Xian-Yun;Liang, Lin-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu
关键词：Agarwood; Aquilaria malaccensis; 2-(2-phenethyl)chromone dimers; Anti-inflammatory activity
-
Discovery of ganodecalone A, from Ganoderma calidophilum for the treatment of acute gastric ulcers by binding to ALOX5 via the MAPK/ NF-κB/iNOS signaling
作者：Liu, Yu;Li, Weikang;Tong, Zhao;Luo, Duqiang;Liu, Yu;Li, Weikang;Tong, Zhao;Luo, Duqiang;Yang, Li;Zhao, Youxing;Wang, Zhen
关键词：Gastric ulcer; Ganoderma calidophilum; Ganodecalone A; Oxidative stress; Inflammation; MAPK/NF-kappa B/iNOS signalling
-
Nauclofficines A and B, two novel monoterpenoid indole alkaloids from the Li folk herb Nauclea officinalis with anti-allergic inflammatory effects on RBL-2H3 cells
作者：Li, Yan-li;Wang, Ting;Wang, Hao;Wang, Qi;Cai, Cai-Hong;Mei, Wen-Li;Dai, Hao-Fu;Huang, Sheng-Zhuo;Dai, Hao-Fu;Huang, Sheng-Zhuo;Li, Yan-li;Xu, Feng-Qing;Wang, Ting;Zhu, Guo-Peng
关键词：Nauclea officinalis; Monoterpenoid indole alkaloid; Li folk medicine; Anti-inflammatory activity; Nauclofficine
-
Two unprecedented 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones with anti-Helicobacter pylori activity from agarwood of Aquilaria sinensis 'Reke 1'
作者：Qin, Ke-Xin;Jian, Jie;Qin, Ke-Xin;Wang, Hao;Yang, Li;Wei, Yan-Mei;Cai, Cai-Hong;Chen, Hui-Qin;Dong, Wen-Hua;Li, Wei;Yan, Xian-Yun;Zeng, Jun;Mei, Wen-Li;Dai, Haofu;Qin, Ke-Xin;Wang, Hao;Yang, Li;Wei, Yan-Mei;Cai, Cai-Hong;Chen, Hui-Qin;Dong, Wen-Hua;Li, Wei;Yan, Xian-Yun;Zeng, Jun;Mei, Wen-Li;Dai, Haofu
关键词：Agarwood; Aquilaria sinensis 'Reke 1 '; 2-(2-Phenylethyl)chromone; Anti -Helicobacter pylori activity
