文献类型： 外文期刊
作者： Li, Wei 1 ; Yang, Yang 1 ; Dong, Wenhua 1 ; Wang, Hao 1 ; Kong, Fandong 1 ; Cai, Caihong 1 ; Mei, Wenli 1 ; Dai, Haofu 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China
2.Hainan Engn Res Ctr Agarwood, Haikou 571101, Hainan, Peoples R China
关键词： Agarwood; Aquilaria crassna; Dimeric 2-(2-phenylethyl)chromone; Cytotoxicity
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
ISSN： 0367-326X
年卷期： 2019 年 133 卷
页码：
收录情况： SCI
摘要： Four new dimeric 2-(2-phenylethyl)chromones (1-4) were isolated from the agarwood of Aquilaria crassna in Laos. All structures were determined based on extensive spectroscopic methods including IR, UV, 1D and 2D NMR, ECD, and HRMS. The structures of compounds 1-3 were characterized by two C-O-C linkages between the two chromone moieties, while compound 4 featured one C-O-C linkage and one C-C bond connecting with two chromone moieties. Compounds 1 and 3 showed weak cytotoxicity against human hepatocellular carcinoma BEL-7402 cell line with IC50 values of 44.68 and 42.10 mu M.
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