Endogenous Retroviruses Function as Gene Expression Regulatory Elements During Mammalian Pre-implantation Embryo Development
文献类型： 外文期刊
作者： Fu, Bo 1 ; Ma, Hong 1 ; Liu, Di 1 ;
作者机构： 1.HeiLongJiang Acad Agr Sci, Inst Anim Husb Res, Harbin 150086, Heilongjiang, Peoples R China
2.Minist Agr Peoples Republ China, Key Lab Combine Planting & Feeding, Harbin 150086, Heilongjiang, Peoples R China
关键词： pre-implantation embryo; endogenous retroviruses; zygotic genome activation; epigenetic reprogramming; somatic cell nuclear transfer
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）
ISSN： 1422-0067
年卷期： 2019 年 20 卷 3 期
页码：
收录情况： SCI
摘要： Pre-implantation embryo development encompasses several key developmental events, especially the activation of zygotic genome activation (ZGA)-related genes. Endogenous retroviruses (ERVs), which are regarded as deleterious genomic parasites, were previously considered to be junk DNA. However, it is now known that ERVs, with limited conservatism across species, mediate conserved developmental processes (e.g., ZGA). Transcriptional activation of ERVs occurs during the transition from maternal control to zygotic genome control, signifying ZGA. ERVs are versatile participants in rewiring gene expression networks during epigenetic reprogramming. Particularly, a subtle balance exists between ERV activation and ERV repression in host-virus interplay, which leads to stage-specific ERV expression during pre-implantation embryo development. A large portion of somatic cell nuclear transfer (SCNT) embryos display developmental arrest and ZGA failure during pre-implantation embryo development. Furthermore, because of the close relationship between ERV activation and ZGA, exploring the regulatory mechanism underlying ERV activation may also shed more light on the enigma of SCNT embryo development in model animals.
- 相关文献
作者其他论文 更多>>
-
PABPN1 functions as a downstream gene of CREB to inhibit the proliferation of preadipocytes
作者：Zhang, Xiao-Han;Li, Jia-Xin;Wu, Xiao-Xu;Zhang, Qian;Yang, Si-Qi;Yang, Xiu-Qin;Tian, Ming;Liu, Di
关键词：CREB; PABPN1; Preadipocyte; Proliferation; Regulatory Axis
-
Two telomere-to-telomere pig genome assemblies and pan-genome analyses provide insights into genomic structural landscape and genetic adaptations
作者：Zong, Wencheng;Chen, Li;Wang, Jinbu;Hou, Xinhua;Liu, Xin;Wang, Ligang;Wang, Lixian;Zhang, Longchao;Chen, Li;Chai, Jie;Wang, Jinyong;Zhang, Dongjie;Tian, Ming;He, Xinmiao;Liu, Di;Zhang, Yuebo;He, Jun;Yin, Yulong;Zhang, Yuebo;He, Jun;Yin, Yulong;An, Yalong;Song, Chengyi;D'Alessandro, Enrico;Li, Mingzhou
关键词：
-
Integration of Multiomics Data Reveals Selection Characteristics of ITGB1 That Are Associated with Size Differentiation in Pigs
作者：Wu, Guandong;Yu, Miao;Liu, Tianxin;Chang, Yang;Liu, Zhonghua;Xu, Chunzhu;Zhang, Dongjie;Liu, Di
关键词：Min pig; selection characteristics; transcriptome; resequencing;
ITGB1 -
Identification and functional analysis of a new cold induced LncRNA44154
作者：Zhang, Dongjie;Ma, Shouzheng;Wang, Liang;Liu, Di
关键词：Pig; Adipogenesis; Lipid metabolism; lncRNA44154
-
Aspartate Metabolism-Driven Gut Microbiota Dynamics and RIP-Dependent Mitochondrial Function Counteract Oxidative Stress
作者：Jin, Shunshun;Wang, Chenyu;He, Yiwen;Zhou, Hui;He, Xinmiao;He, Liuqin;Wu, Jian;Wang, Chenyu;He, Yiwen;Tang, Yulong;Huang, Le;Zhou, Hui;Peng, Can;Li, Tiejun;Yin, Yulong;He, Liuqin;Jin, Shunshun;Wu, Ziping;Liu, Di;Feng, Yanzhong;Chen, Heshu;He, Xinmiao;Yang, Guan;Qiu, Jiazhang;Yin, Yulong
关键词：aspartate; microbiota; oxidative stress; RIP pathway
-
Isolation and Characterization of Seneca Valley Virus From Pig Transboundary Spread to the Mink Infection
作者：Qin, Ziliang;Chen, Chao;Chen, Shaojun;Nai, Zida;Li, Gang;Liu, Di;Jiang, Xinpeng;He, Xinmiao;Wang, Wentao;Wang, Fang;Tian, Ming;He, Haijuan;Chen, Heshu;Liu, Di;Wang, Yao
关键词：cross-host transmission; mink; Seneca Valley virus
-
Positive selection on rare variants of IGF1R and BRD4 underlying the cold adaptation of wild boar
作者：Chen, Jianhai;Xu, Zhixiang;Guo, Yapin;Kuang, Renzuo;Zhao, Yunxia;Zhao, Shuhong;Chen, Jianhai;Xia, Shengqian;Jia, Yangying;Chen, Jianhai;Jakovlic, Ivan;Jakovlic, Ivan;Jakovlic, Ivan;Sablin, Mikhail;Zhong, Jie;Tran, Nhien Thuy Thi;Tran, Nhien Thuy Thi;Yang, Hao;Ma, Hong;Liu, Di;Sprem, Nikica;Han, Jianlin;Zhao, Yunxia;Zhao, Shuhong
关键词：
