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Responses of antioxidant defenses in the clam Mactra veneriformis to 2,2 ',4, 4 '-tetrabromodiphenyl ether exposure

文献类型： 外文期刊

作者： Dong, Shihang 1 ; Yang, Yanyan 2 ; Cheng, Bo 3 ; Ren, Chuanbo 2 ; Zhang, Huawei 2 ; Xu, Hua 4 ; Zhu, Na 1 ; Wang, Wanshen 1 ;

作者机构： 1.Ludong Univ, Sch Agr, Yantai 264025, Peoples R China

2.Shandong Marine Resource & Environm Res Inst, Shandong Prov Key Lab Restorat Marine Ecol, Yantai 264006, Peoples R China

3.Chinese Acad Fishery Sci, Aquat Prod Qual & Stand Res Ctr, Beijing 100141, Peoples R China

4.Yantai Environm Monitoring Ctr Stn, Yantai 264000, Peoples R China

5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China

关键词： Catalase; Glutathione peroxidase; Superoxide dismutase; 2,2 ',4,4 '-Tetrabromodiphenyl ether; Malondialdehyde; Mactra veneriformis

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：3.228； 五年影响因子：3.289 ）

ISSN： 1532-0456

年卷期： 2019 年 217 卷

页码：

收录情况： SCI

摘要： Antioxidant enzymes play essential roles against oxidative stress caused by 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), which is ubiquitous in marine environment and organisms. However, research on antioxidant responses to BDE-47 in marine bivalves is scarce. In this study, we identified the full-length cDNA of catalase (CAT), and glutathione peroxidase (GPx) in the clam Mactra veneriformis. Subsequently, the responses of CAT, GPx, and copper, zinc-superoxide dismutase (Cu, Zn-SOD) were investigated in the clams exposed to 0.1, 1, and 10 mu g/L BDE-47 for 7 days, and then depurated in natural seawater for 3 days. MvCAT and MvGPx contained conserved sequences. The deduced amino acid sequences shared high similarity with CATs and GPxs in other mollusks. M. veneriformis accumulated BDE-47 in a dose-dependent manner and eliminated BDE-47 poorly. BDE-47 induced a time- and dose-dependent increase of malondialdehyde content. Both the dose and the duration had significant effect on mRNA expressions and activities of the three antioxidants. Cu, Zn-SOD responded to BDE-47 earlier than CAT and GPx. The antioxidant responses could recover after depuration. These results suggested that M. veneriformis could accumulate BDE-47 efficiently. Antioxidant enzymes were triggered to counter the oxidative stress generated by BDE-47. Cu, Zn-SOD acted as the first defense against oxidative stress, while CAT and GPx intervened later. This study is therefore helpful in understanding the antioxidant responses to PBDEs in marine bivalves.

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