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Dual Transcriptomic Analysis Reveals a Delayed Antiviral Response of Haliotis diversicolor supertexta against Haliotid Herpesvirus-1

文献类型： 外文期刊

作者： Bai, Chang-Ming 1 ; Zhang, Shu-Min 1 ; Li, Ya-Na 1 ; Xin, Lu-Sheng 1 ; Rosani, Umberto 5 ; Wang, Chong-Ming 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Qingdao Key Lab Mariculture Epidemiol & Biosecur, Key Lab Maricultural Organism Dis Control, Minist Agr,Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China

2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China

3.Dalian Ocean Univ, Dept Fisheries & Life Sci, Dalian 116023, Peoples R China

4.Tianjin Agr Univ, Dept Fisheries, Tianjin 300380, Peoples R China

5.Univ Padua, Dept Biol, I-35121 Padua, Italy

6.Helmholtz Ctr Polar & Marine Res, AWI, Wadden Sea Stn Sylt, D-25992 List Auf Sylt, Germany

关键词： abalone; transcriptome; immune-related genes; apoptosis; HaHV-1

期刊名称：VIRUSES-BASEL （ 影响因子：5.048； 五年影响因子：5.127 ）

ISSN： 1999-4915

年卷期： 2019 年 11 卷 4 期

页码：

收录情况： SCI

摘要： Haliotid herpesvirus-1 (HaHV-1) is the first identified gastropod herpesvirus, causing a highly lethal neurologic disease of abalone species. The genome of HaHV-1 has been sequenced, but the functions of the putative genes and their roles during infection are still poorly understood. In the present study, transcriptomic profiles of Haliotis diversicolor supertexta at 0, 24 and 60 h post injection (hpi) with HaHV-1 were characterized through high-throughput RNA sequencing. A total of 448 M raw reads were obtained and assembled into 2.08 x 10(5) unigenes with a mean length of 1486 bp and an N50 of 2455 bp. Although we detected increased HaHV-1 DNA loads and active viral expression at 24 hpi, this evidence was not linked to significant changes of host transcriptomic profiles between 0 and 24 hpi, whereas a rich immune-related gene set was over-expressed at 60 hpi. These results indicate that, at least at the beginning of HaHV-1 infection, the virus can replicate with no activation of the host immune response. We propose that HaHV-1 may evolve more effective strategies to modulate the host immune response and hide during replication, so that it could evade the immune surveillance at the early stage of infection.

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