Highly Effective Bone Fusion Induced by the Interbody Cage Made of Calcium Silicate/Polyetheretherketone in a Goat Model
文献类型： 外文期刊
作者： Chu, Linyang 1 ; Li, Rui 2 ; Liao, Zhenhua 2 ; Yang, Ying 1 ; Dai, Jianjun 3 ; Zhang, Kai 1 ; Zhang, Feng 1 ; Xie, Youzhu 1 ;
作者机构： 1.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthoped Surg, Shanghai Key Lab Orthoped Implants,Sch Med, Shanghai 200011, Peoples R China
2.Tsinghua Univ Shenzhen, Res Inst, Shenzhen 518057, Guangdong, Peoples R China
3.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Sci, Shanghai 200011, Peoples R China
4.East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China
关键词： PEEK; calcium silicate; interbody fusion cage; spine surgery
期刊名称：ACS BIOMATERIALS SCIENCE & ENGINEERING （ 影响因子：4.749； 五年影响因子：5.289 ）
ISSN： 2373-9878
年卷期： 2019 年 5 卷 5 期
页码：
收录情况： SCI
摘要： Interbody fusion surgery is often used to settle matters such as degenerative disc disease or disc herniation in clinical orthopedics. Considering the deficiencies of the current treatment methods, we developed an interbody fusion cage made of calcium silicate (CS)/polyetheretherketone (PEEK) and hoped that the bioactive cage could exhibit great fusion ability and maintain stable mechanical function. In the goat model of cervical interbody fusion, the CS/PEEK cage showed stronger interbody fusion at 12 and 26 weeks compared with pure PEEK cage based on the X-ray analysis. The micro-CT scanning and analysis indicated that the CS/PEEK cage induced more new bone ingrowth than the PEEK cage and led to nearly complete interbody fusion at 26 weeks. Moreover, the CS/PEEK group showed excellent mechanical stability and stiffness as evaluated by the spine kinematic assay at the time points. The histological assessment showed the rapid osseointegration and mineralized bone formation around the CS/PEEK cage. This study confirmed that the bioactive CS/PEEK cage is capable of inducing highly effective bone fusion and has high potential to be used in the clinics of spine surgery.
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