文献类型： 外文期刊
作者： Ge, Xueping 1 ; Sun, Chunxiao 1 ; Feng, Yanyan 1 ; Wang, Lingzhi 1 ; Peng, Jixing 3 ; Che, Qian 1 ; Gu, Qianqun 1 ; Zhu, 1 ;
作者机构： 1.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Shandong, Peoples R China
3.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Minist Agr & Rural Affairs, Key Lab Testing & Evaluat Aquat Prod Safety & Qua, Qingdao 266071, Shandong, Peoples R China
关键词： anthraquinone derivatives; Sporendonema casei; marine-derived fungus; cytotoxic activities; antibacterial activities
期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）
ISSN： 1660-3397
年卷期： 2019 年 17 卷 6 期
页码：
收录情况： SCI
摘要： Five new anthraquinone derivatives, auxarthrols D-H (1-5), along with two known analogues (6-7), were obtained from the culture of the marine-derived fungus Sporendonema casei. Their structures, including absolute configurations, were established on the basis of NMR, HRESIMS, and circular dichroism (CD) spectroscopic techniques. Among them, compound 4 represents the second isolated anthraquinone derivative with a chlorine atom, which, with compound 6, are the first reported anthraquinone derivatives with anticoagulant activity. Compounds 1 and 3 showed cytotoxic activities with IC50 values from 4.5 mu M to 22.9 mu M, while compounds 1, 3-4, and 6-7 showed promising antibacterial activities with MIC values from 12.5 mu M to 200 mu M. In addition, compound 7 was discovered to display potential antitubercular activity for the first time.
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