Secondary Metabolites Produced by Combined Culture of Penicillium crustosum and a Xylaria sp.
文献类型： 外文期刊
作者： Yu, Guihong 1 ; Sun, Zichao 1 ; Peng, Jixing 3 ; Zhu, Meilin 1 ; Che, Qian 1 ; Zhang, Guojian 1 ; Zhu, Tianjiao 1 ; Gu, Q 1 ;
作者机构： 1.Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Shandong, Peoples R China
2.Qingdao Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Shandong, Peoples R China
3.Chinese Acad Fishery Sci, Key Lab Testing & Evaluat Aquat Prod Safety & Qua, Minist Agr & Rural Affairs, Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）
ISSN： 0163-3864
年卷期： 2019 年 82 卷 7 期
页码：
收录情况： SCI
摘要： Four new alkyl aromatics, penixylarins A-D (1-4), along with the known biogenetically related 1,3-dihydroxy-5-(12-hydroxyheptadecyl)benzene (5) and 1,3dihydroxy-5-(12-sulfoxyheptadecyl)benzene (6), were isolated from a mixed culture of the Antarctic deep-sea-derived fungus Penicillium crustosum PRB-2 and the mangrove-derived fungus Xylaria sp. HDN13-249. UPLC-MS data and an analysis of structural features showed that compounds 1 and 2 were produced by collaboration of the two fungi, while compounds 3-6 could be produced by Xylaria sp. HDN13-249 alone, but in noticeably increased quantities by cocultivation. Compounds 2, 3, 5, and 6 showed antibacterial activity against a panel of strains, and compound 3 possessed potential antituberculosis effects (MIC = 6.25 mu M against Mycobacterium phlei).
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