"Omics" data unveil early molecular response underlying limb regeneration in the Chinese mitten crab, Eriocheir sinensis
文献类型： 外文期刊
作者： Wang, Jun 1 ; Chen, Xiaowen 1 ; Hou, Xin 1 ; Wang, Jingan 1 ; Yue, Wucheng 1 ; Huang, Shu 1 ; Xu, Gangchun 2 ; Yan, Jizhou 1 ; Lu, Guoqing 3 ; Hofreiter, Michael 4 ; Li, Chenhong 1 ; Wang, Chenghui 1 ;
作者机构： 1.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai Engn Res Ctr Aquaculture, Key Lab Freshwater Aquat Genet Resources certified, Shanghai 201306, Peoples R China
2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resources, Wuxi 214081, Peoples R China
3.Univ Nebraska Omaha, Dept Biol, Omaha, NE 68182 USA
4.Univ Potsdam, Inst Biochem & Biol, Fac Sci, Evolutionary Adapt Genom, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany
期刊名称：SCIENCE ADVANCES （ 影响因子：14.957； 五年影响因子：16.895 ）
ISSN： 2375-2548
年卷期： 2022 年 8 卷 37 期
页码：
收录情况： SCI
摘要： Limb regeneration is a fascinating and medically interesting trait that has been well preserved in arthropod lineages, particularly in crustaceans. However, the molecular mechanisms underlying arthropod limb regeneration remain largely elusive. The Chinese mitten crab Eriocheir sinensis shows strong regenerative capacity, a trait that has likely allowed it to become a worldwide invasive species. Here, we report a chromosome-level genome of E. sinensis as well as large-scale transcriptome data during the limb regeneration process. Our results reveal that arthropod -specific genes involved in signal transduction, immune response, histone methylation, and cuticle development all play fundamental roles during the regeneration process. Particularly, Innexin2-mediated signal transduction likely facilitates the early stage of the regeneration process, while an effective crustacean-specific prophenoloxidase system (ProPo-AS) plays crucial roles in the initial immune response. Collectively, our findings uncover novel genetic pathways pertaining to arthropod limb regeneration and provide valuable resources for studies on regeneration from a comparative perspective.
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