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Prenylated cyclohexene-type meroterpenoids and sulfur-containing xanthones produced by Pseudopestalotiopsis theae

文献类型： 外文期刊

作者： Akone, Sergi Herve 1 ; Wang, Hao 5 ; Mouelle, Eitel Ngoh Misse 2 ; Mandi, Attila 6 ; Kurtan, Tibor 6 ; Koliye, Pierre Roger 2 ; Hartmann, Rudolf 7 ; Bhatia, Sanil 8 ; Yang, Jing 8 ; Muller, Werner E. G. 9 ; Lai, Daowan 10 ; Liu, Zhen 1 ; Kalscheuer, Rainer 1 ; Proksch, Peter 1 ;

作者机构： 1.Heinrich Heine Univ, Inst Pharmaceut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany

2.Univ Douala, Dept Chem, Fac Sci, POB 24157, Douala, Cameroon

3.Univ Saarland, Helmholtz Ctr Infect Res, Helmholtz Inst Pharmaceut Res Saarland HIPS, Dept Microbial Nat Prod, D-66123 Saarbrucken, Germany

4.Univ Saarland, Dept Pharm, D-66123 Saarbrucken, Germany

5.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, 4 Xueyuan Rd, Haikou 571101, Hainan, Peoples R China

6.Univ Debrecen, Dept Organ Chem, Egyet Ter 1, POB 400, H-4002 Debrecen, Hungary

7.Forschungszentrum Julich, Inst Complex Syst Strukturbiochem ICS6, Wilhelm Johnen Str, D-52428 Julich, Germany

8.Heinrich Heine Univ Duesseldorf, Fac Med, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany

9.Univ Med Johannes Gutenberg Univt Mainz, Inst Physiol Chem, D-55128 Mainz, Germany

10.China Agr Univ, Dept Plant Pathol, Coll Plant Protect, Beijing 100193, Peoples R China

关键词： Pseudopestalotiopsis theae; Amphisphaeriaceae; Endophytic fungus; Sulfur-containing xanthone; Meroterpenoids; Cytotoxicity

期刊名称：PHYTOCHEMISTRY （ 影响因子：4.004； 五年影响因子：4.129 ）

ISSN： 0031-9422

年卷期： 2022 年 197 卷

页码：

收录情况： SCI

摘要： Chemical investigation of the fungal endophyte Pseudopestalotiopsis theae isolated from leaves of Caloncoba welwitschii, collected in Cameroon, resulted in two previously undescribed sulfur-containing xanthone derivatives sydoxanthones D and E, in addition to three previously undescribed monomeric diisoprenyl-cyclohexene-type meroterpenoids biscognienynes D-F and five known natural products. The structures of the undescribed compounds were unambiguously identified by their mass spectra and by extensive 1D and 2D NMR spectroscopic analysis. Mosher's reaction was performed to determine the absolute configuration of sydoxanthones D and E while TDDFT-ECD calculations were used to assign the configuration of biscognienyne D. Biscognienynes B and D showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with IC50 values of 7.7 and 6.7 mu M and against the human leukemic cell lines HL60, and Hal-01 with IC50 values ranging from 4.3 to 12.1 mu M.

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