Dimeric Tetracenomycin Derivatives from a Taklamakan Desert-Derived Streptomyces sp. HDN154193
文献类型： 外文期刊
作者： Xing, Li 1 ; Chang, Yimin 1 ; Zhang, Xiaoqian 1 ; Hou, Xuewen 1 ; Han, Yaxin 1 ; Shah, Mudassir 2 ; Zhu, Tianjiao 1 ; Peng, Jixing 4 ; Zhang, Guojian 1 ; Che, Qian 1 ; Li, Dehai 1 ;
作者机构： 1.Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Shandong, Peoples R China
2.Minist Agr & Rural Affairs, Key Lab Testing & Evaluat Aquat Prod Safety & Qua, Beijing 100125, Peoples R China
3.Abbottabad Univ Sci & Technol, Dept Pharm, Abbottabad 22010, Kpk, Pakistan
4.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China
5.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Shandong, Peoples R China
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.803； 五年影响因子：4.869 ）
ISSN： 0163-3864
年卷期： 2022 年 85 卷 1 期
页码：
收录情况： SCI
摘要： Bitetracenomycin A (1) and its diastereomers [(+/-)-bitetracenomycin B, (+/-)-2] were discovered from the cultures of Streptomyces sp. HDN154193. Compounds 1 and (+/-)-2 were the first tetracenomycin dimers obtained from a natural source with sp(3) methine protons at the bridge positions (C-12/12'), which also exhibited broad-spectrum antibacterial activity. The racemate (+/-)-2 was semisynthesized and separated into enantiomers (+)-2 and (-)-2, and the absolute configurations were determined by specific rotation and ECD data. These metabolites exhibited potent antibacterial activity especially against drug-resistant strains (MRSA and MRCNS) with MIC values ranging from 1.0 to 1.9 mu g/mL.
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