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Synthesis and Evaluation of New Halogenated GR24 Analogs as Germination Promotors for Orobanche cumana

文献类型： 外文期刊

作者： Chen, Yuchao 1 ; Kuang, Yi 4 ; Shi, Liyang 4 ; Wang, Xing 4 ; Fu, Haoyu 4 ; Yang, Shengxiang 4 ; Sampietro, Diego A. 5 ;

作者机构： 1.Anhui Univ Chinese Med, Sch Pharm, Hefei, Peoples R China

2.China Acad Chinese Med Sci, Natl Resources Ctr Chinese Mat Med, State Key Lab Dao Herbs Breeding Base, Beijing, Peoples R China

3.Ningxia Acad Agr & Forestry Sci, Agr Biotechnol Ctr, Yinchuan, Ningxia, Peoples R China

4.Zhejiang A&F Univ, Zhejiang Prov Collaborat Innovat Ctr Bamboo Resou, Linan, Peoples R China

5.Natl Univ Tucuman, LABIFITO, San Miguel De Tucuman, Argentina

关键词： strigolactones; Orobanche cumana; parasitic weeds; GR24 analogs; suicidal germination

期刊名称：FRONTIERS IN PLANT SCIENCE （ 影响因子：5.754； 五年影响因子：6.612 ）

ISSN： 1664-462X

年卷期： 2021 年 12 卷

页码：

收录情况： SCI

摘要： Orobanche and Striga are parasitic weeds extremely well adapted to the life cycle of their host plants. They cannot be eliminated by conventional weed control methods. Suicidal germination induced by strigolactones (SLs) analogs is an option to control these weeds. Here, we reported two new halogenated (+)-GR24 analogs, named 7-bromo-GR24 (7BrGR24) and 7-fluoro-GR24 (7FGR24), which were synthesized using commercially available materials following simple steps. Both compounds strongly promoted seed germination of Orobanche cumana. Their EC50 values of 2.3 +/- 0.28x10(-8)M (7BrGR24) and 0.97 +/- 0.29x10(-8)M (7FGR24) were 3- and 5-fold lower, respectively, than those of (+)-GR24 and rac-GR24 (EC50=5.1 +/- 1.32-5.3 +/- 1.44x10(-8); p<0.05). The 7FGR24 was the strongest seed germination promoter tested, with a stimulation percentage of 62.0 +/- 9.1% at 1.0x10(-8)M and 90.9 +/- 3.8% at 1.0x10(-6)M. It showed higher binding affinity (IC50=0.189 +/- 0.012 mu M) for the SL receptor ShHTL7 than (+)-GR24 (IC50=0.248 +/- 0.032 mu M), rac-GR24 (IC50=0.319 +/- 0.032 mu M), and 7BrGR24 (IC50=0.521 +/- 0.087 mu M). Molecular docking experiments indicated that the binding affinity of both halogenated analogs to the strigolactone receptor OsD14 was similar to that of (+)-GR24. Our results indicate that 7FGR24 is a promising agent for the control of parasitic weeds.

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