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Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1

文献类型： 外文期刊

作者： Cao, Xi 1 ; Guo, Lei 2 ; Cai, Caihong 1 ; Kong, Fandong 3 ; Yuan, Jingzhe 1 ; Gai, Cuijuan 1 ; Dai, Haofu 1 ; Wang, Pei 1 ; Mei, Wenli 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Hainan Inst Trop Agr Resources, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou, Hainan, Peoples R China

2.Jiangsu Ocean Univ, Coinnovat Ctr Jiangsu Marine Bioind Technol, Jiangsu Key Lab Marine Bioresources & Environm, Lianyungang, Peoples R China

3.Guangxi Univ Nationalities, Guangxi Collaborat Innovat Ctr Chem & Engn Forest, Guangxi Key Lab Chem & Engn Forest Prod,Sch Chem, Key Lab Chem & Engn Forest Prod,State Ethn Affair, Nanning, Peoples R China

关键词： mangrove-derived fungus; Cladosporium sp.; metabolites; cytotoxicity; a; -glycosidase inhibitor

期刊名称：FRONTIERS IN CHEMISTRY （ 影响因子：5.545； 五年影响因子：5.869 ）

ISSN： 2296-2646

年卷期： 2021 年 9 卷

页码：

收录情况： SCI

摘要： Two new benzoic acids, cladoslide A (1) and cladoslide B (2); one new beta-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with the previously reported N-acetyl-beta-oxotryptamine (5), (4S,5S,11R)-iso-cladospolide B (6), (4S,5S,11S)-iso-cladospolide B (7), and (4R,5S,11R)-iso-cladospolide B (8). Their structures were elucidated by spectroscopic analysis, Rh-2(OCOCF3)(4)-induced ECD experiments, and Marfey's method. Compound 1 showed cytotoxicity against the K562 cell line with IC50 values of 13.10 +/- 0.08 mu M. Moreover, compounds 1 and 5 exhibited inhibitory activity against alpha-glycosidase with IC50 values of 0.32 +/- 0.01 mM and 0.17 +/- 0.01 mM, respectively.

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