Mechanistic insights into antihypertensive activity of mushroom-derived protein-peptides via metabolomic and proteomic approaches
文献类型： 外文期刊
作者： Li, Wen 1 ; Chen, Wanchao 1 ; Wu, Di 1 ; Zhang, Zhong 1 ; Liu, Peng 1 ; Li, Zhengpeng 1 ; Yang, Yan 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Shanghai Guosen Biotech Co Ltd, Inst Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South,Na, Shanghai 201403, Peoples R China
关键词： Stropharia rugosoannulata mushroom; Protein-peptide; Metabolomics; Proteomics; Antihypertensive mechanism
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）
ISSN： 0141-8130
年卷期： 2024 年 283 卷
页码：
收录情况： SCI
摘要： Stropharia rugosoannulata mushroom peptides have well-defined sequences, specific structures, and excellent antihypertensive activity. In this study, metabolomic and proteomic analyses revealed the antihypertensive mechanism of mushroom-derived protein-peptides, GQEDYDRLRPL (GL-11P) and KSWDDFFTR (KR-9P), to demonstrate their potential antihypertensive buck-regulation systems and pathways. Protein-peptides were predominantly down-regulated expression of endogenous metabolites in antihypertensive regulation, and bile acid analogs were key endogenous differentially expressed metabolic markers. Antihypertensive treatment with protein-peptides activated the immune and signal transduction systems, affected extracellular regions, metal ion binding, and receptor binding ability. The ECM-receptor interaction pathway, with differentially expressed proteins in antihypertensive treatment, distinguished the protein-peptides from blank control and was also a critical pathway that distinguished the two protein-peptides. Up-regulatory pathways of protein expression dominated by GL-11P's antihypertensive regulation, while down-regulatory pathways of protein expression dominated by KR-9P's antihypertensive regulation. Protein-peptides exerted antihypertensive regulatory effects by enhancing immune responses, up-regulating protein and enzyme binding capacity, and down-regulating inflammatory mediator release. Differentially expressed protein interactions produced in protein-peptides antihypertensive therapy mostly up-regulated the Reactome pathway and were dominated by immune system regulation. This study provided data support for utilizing mushroom-derived protein-peptides in antihypertensive therapy, and enriched the theoretical basis of protein-peptides' antihypertensive regulation mechanisms.
- 相关文献
作者其他论文 更多>>
-
Comparison of the Bacterial and Fungal Communities and Metabolic Functions of Cottonseed Hull Waste Compost Associated with High and Low Yields of Straw Mushroom Volvariella volvacea
作者：Kakumyan, Pattana;Yang, Lin;Liu, Shunjie;Yu, Changxia;Li, Zhengpeng;Chen, Mingjie;Zhao, Yan;Kakumyan, Pattana;Popluechai, Siam;Kakumyan, Pattana;Popluechai, Siam
关键词：straw mushroom; cotton waste compost; microbial diversity; physicochemical properties; biological efficiency
-
Nanoliposome based strategy for enhancing bioavailability and antitumor activity of polyphenol from Sanghuangporus vaninii
作者：Liu, Peng;Wang, Yuyang;Zhang, Zhong;Wu, Di;Chen, Wanchao;Li, Wen;Yang, Yan;Liu, Peng;Wang, Yuyang;Zhang, Zhong;Wu, Di;Chen, Wanchao;Li, Wen;Yang, Yan;Liu, Peng;Liu, Junbo;Wang, Weike
关键词：Sanghuangporus vaninii; Nanoliposome; Liver tumor; Polyphenol; Bioavailability
-
Targeted isolation and AI-based analysis of edible fungal polysaccharides: Emphasizing tumor immunological mechanisms and future prospects as mycomedicines
作者：Li, Tingting;Bi, Yong;Li, Tingting;Rui, Chuang;Ren, Lu;Wang, Qin;Dai, Mingcheng;Yang, Yan
关键词：Keywords; Edible fungal polysaccharide; Structural characterization; Gut microbiota; Tumor microenvironment; Mycomedicines; Deep learning; Glycan structure prediction"
-
Novel Umami Peptides from Lentinula edodes: Evaluation of the Umami Enhancing Effect Using Biosensors and Molecular Simulation
作者：Zhao, Shilong;Cui, Zhiyong;Zheng, Yuqian;Yu, Yanyang;Zhou, Changlin;Zhou, Quanlong;Zhang, Amin;Guo, Xueqian;Liu, Yuan;Wang, Wenli;Zhao, Shilong;Wang, Shengnan;Xu, Changhua;Liu, Yuan;Yang, Yan;Luo, Zisheng
关键词：
Lentinula edodes ; umami peptide; umami enhancing effect; biosensor; moleculardynamics simulation -
The ENaC taste receptor's perceived mechanism of mushroom salty peptides revealed by molecular interaction analysis
作者：Li, Wen;Chen, Wanchao;Wu, Di;Zhang, Zhong;Liu, Peng;Li, Zhengpeng;Yang, Yan
关键词：
-
A novel directed enzymolysis strategy for the preparation of umami peptides in Stropharia rugosoannulata and its mechanism of taste perception
作者：Chen, Daoyou;Rong, Mingli;Yuan, Zhaoting;Miao, Tingwei;Song, Hucheng;Zhang, Lujia;Yang, Yan;Zhang, Chuanxi;Wei, Hao;Tang, Shuting;Jiang, Haiming
关键词：Stropharia rugosoannulata; Directed enzymolysis; Virtual screening; Umami peptide; Molecular simulation
-
Anti-hyperuricemia effects of a polysaccharide-protein complex from Lentinula edodes mediated by gut-kidney axis
作者：Xiong, Xinyi;Liu, Peng;Liu, Liping;Feng, Jie;Zhang, Jingsong;Yan, Mengqiu;Liu, Yanfang;Xiong, Xinyi;Xiong, Xinyi;Liu, Peng;Liu, Liping;Feng, Jie;Zhang, Jingsong;Yan, Mengqiu;Liu, Yanfang
关键词：Hyperuricemia; Lentinula edodes; Polysaccharide-protein complex; Gut microbiota; Gut-kidney axis
