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Epigallocatechin-3-gallate inhibits replication of white spot syndrome virus in the freshwater crayfish Procambarus clarkii

文献类型： 外文期刊

作者： Zhang, Yitong 1 ; Wen, Jinxuan 1 ; Xu, Yao 1 ; Wang, Hao 1 ; Lu, Liqun 1 ; Song, Rui 5 ; Zou, Jixing 6 ;

作者机构： 1.Shanghai Ocean Univ, Natl Pathogen Collect Ctr Aquat Anim, Shanghai, Peoples R China

2.Chinese Acad Fishery Sci, Beidaihe Cent Expt Stn, Qinhuangdao, Hebei, Peoples R China

3.Pilot Natl Lab Marine Fisheries Sci & Technol, Qingdao, Peoples R China

4.Shanghai Ocean Univ, Key Lab Freshwater Aquat Genet Resources, Minist Agr, Shanghai, Peoples R China

5.Hunan Fisheries Sci Inst, Changsha, Peoples R China

6.South China Agr Univ, Guangzhou, Peoples R China

关键词： crayfish; epigallocatechin-3-gallate; Procambarus clarkii; white spot syndrome virus

期刊名称：JOURNAL OF FISH DISEASES （ 影响因子：2.58； 五年影响因子：2.64 ）

ISSN： 0140-7775

年卷期： 2022 年 45 卷 3 期

页码：

收录情况： SCI

摘要： The freshwater crayfish Procambarus clarkii is native to North America and Mexico, and it was introduced to China in 1929. The production and consumption of P. clarkii in China are the highest worldwide, reaching 208.96 million tons in 2020. The white spot syndrome virus (WSSV) is a major pathogen that affects shrimp, crayfish, crabs and lobsters, and it has caused widespread loss to the P. clarkii industry. Epigallocatechin-3-gallate (EGCG), a small-molecule compound, has a multitude of biological functions and the ability to bind to the 37 kDa/67 kDa laminin receptor (LamR). EGCG has potential antiviral effects against WSSV. In this study, we evaluated the potential anti-WSSV applications of EGCG in P. clarkii. We demonstrated that various concentrations (10 mu g/g center dot bw, 20 mu g/g center dot bw and 40 mu g/g center dot bw) of EGCG can suppress WSSV infection in P. clarkii. Histopathological examination revealed no characteristic pathological changes due to EGCG administration in P. clarkii tissues. Furthermore, pharmacokinetics studies of EGCG in P. clarkii revealed its rapid absorption (T-max = 2 h), and the peak concentrations of EGCG were 73.78 mu g/g in the liver and 24.87 mu g/g in the muscle. Our results indicate the high potential applications of EGCG against WSSV in P. clarkii.

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