文献类型： 外文期刊
作者： Tan, Luyi 1 ; Zhu, Chenyu 1 ; Zhang, Xinyu 1 ; Fu, Jiaqi 1 ; Huang, Tingting 1 ; Zhang, Wenji 2 ; Zhang, Wenjuan 1 ;
作者机构： 1.Jinan Univ, Sch Med, Dept Publ Hlth & Prevent Med, Guangzhou 510632, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Crops Res Inst,Guangdong Prov Engn & Technol, Key Lab Crop Genet Improvement Guangdong Prov, Res Ctr Tobacco Breeding & Comprehens Utilizat, Guangzhou 510640, Guangdong, Peoples R China
关键词： Cancer; Mitochondrial RNA methylation; Mitochondrial RNA methyltransferase; Nuclear-mitochondrial crosstalk; Drugs
期刊名称：BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER （ 影响因子：8.3； 五年影响因子：11.6 ）
ISSN： 0304-419X
年卷期： 2024 年 1879 卷 6 期
页码：
收录情况： SCI
摘要： Mitochondria have a complete and independent genetic system with necessary biological energy for cancer occurrence and persistence. Mitochondrial RNA (mt-RNA) methylation, as a frontier in epigenetics, has linked to cancer progression with growing evidences. This review has comprehensively summarized detailed mechanisms of mt-RNA methylation in regulating cancer proliferation, metastasis, and immune infiltration from the mt-RNA methylation sites, biological significance, and its methyltransferases. The mt-RNA methylation also plays a very significant role via epigenetic crosstalk between nucleus and mitochondria. Importantly, the unique structures and functional characteristics of mt-RNA methyltransferases and the potential targeting treatment drugs for cancer are also analyzed. Revealing human mt-RNA methylation regulatory system and the relationship with cancer will contribute to identifying potential biomarkers and therapeutic targets for precise prevention, detection, intervention and treatment in the future.
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