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Role of creatine supplementation on the myofibre characteristics and muscle protein synthesis of grass carp (Ctenopharyngodon idellus)

文献类型： 外文期刊

作者： Tian, Juan 1 ; Cheng, Xiaoli 1 ; Yu, Lijuan 1 ; Jiang, Ming 1 ; Gao, Weihua 2 ; Lu, Xing 1 ; Zhang, Wenbing 2 ; Wen, Hua 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Key Lab Freshwater Biodivers Conservat, Yangtze River Fisheries Res Inst, Minist Agr & Rural Affairs, Wuhan 430223, Peoples R China

2.Yangtze Univ, Coll Anim Sci, Jingzhou, Peoples R China

关键词： Creatine; Grass carp; Flesh quality; Myofibre; TOR

期刊名称：BRITISH JOURNAL OF NUTRITION （ 影响因子：3.6； 五年影响因子：4.0 ）

ISSN： 0007-1145

年卷期： 2023 年 130 卷 2 期

页码：

收录情况： SCI

摘要： To assess the role of dietary creatine on myofibre characteristics and protein synthesis in muscle, we fed grass carp (Ctenopharyngodon idellus, initial body weight: 88 center dot 47 +/- 1 center dot 44 g) creatine-supplemented diets (1 center dot 84, 5 center dot 91, 8 center dot 48 and 15 center dot 44 g/kg diet) for 8 weeks. Creatine supplementation did not affect growth performance, but significantly increased creatine contents in muscle and liver. At 8 center dot 48 g/kg, creatine decreased the activities of alanine transaminase and aspartate aminotransferase in serum and improved hardness and chewiness of muscle due to shorter myofibre mean diameter, higher myofibre density and the frequencies of the diameters of classes I and III and collagen content, longer sarcomere length and upregulated mRNA levels of slow myosin heavy chains. Creatine supplementation upregulated the mRNA expressions of myogenic regulatory factors. The 8 center dot 48 g/kg creatine-supplemented diet significantly increased the contents of protein, total amino acids (AA), essential AA and free flavour AAs in muscle, the protein levels of insulin-like growth factor I, myogenic differentiation antigen and PPAR-gamma coactlvator-1 alpha in muscle and stimulated the phosphorylation of target of rapamycin (TOR) pathway in muscle. In summary, 8 center dot 48 mg/kg creatine improved fish health and skeletal muscle growth and increased hardness and protein synthesis in muscle of grass carp by affecting myofibre characteristics and the TOR signalling pathway. A second-order regression model revealed that the optimal dietary creatine supplementation of grass carp ranges between 8 center dot 48 and 12 center dot 04 g/kg.

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