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Six unprecedented 2-(2-phenethyl)chromone dimers from agarwood of Aquilaria filaria

文献类型： 外文期刊

作者： Wei, Yuan 1 ; Dong, Wen-Hua 1 ; Li, Wei 1 ; Zeng, Jun 1 ; Chen, Hui-Qin 1 ; Huang, Sheng-Zhuo 1 ; Yang, Li 1 ; Wang, Ya-Li 1 ; Guo, Zhi-Yong 2 ; Dai, Hao-Fu 1 ; Wang, Hao 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Int Joint Res Ctr Agarwood, Hainan Engn Res Ctr Agarwood,Natl Key Lab Trop Cro, Haikou 571101, Peoples R China

2.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

关键词： Aquilaria filaria; Agarwood; 2-(2-Phenylethyl)chromone dimer; Tyrosinase inhibitory activity; Anti-inflammatory activity

期刊名称：FITOTERAPIA （ 影响因子：3.4； 五年影响因子：3.3 ）

ISSN： 0367-326X

年卷期： 2024 年 175 卷

页码：

收录情况： SCI

摘要： Six new dimeric 2-(2-phenylethyl)chromones ( 1 - 6 ) were successfully isolated from the ethanol extract of agarwood of Aquilaria filaria from Philippines under HPLC-MS guidance. Compounds 1 - 6 are all dimers formed by linking 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone and flindersia 2-(2-phenylethyl)chromone via a single ether bond, and the linkage site (C5-O-C8 '' ) of compound 2 is extremely rare. A variety of spectroscopic methods were used to ascertain their structures, including extensive 1D and 2D NMR spectroscopic analysis, HRESIMS, and comparison with literature. The in vitro tyrosinase inhibitory and anti-inflammatory activities of each isolate were assessed. Among these compounds, compound 2 had a tyrosinase inhibition effect with an IC 50 value of 27.71 +/- 2.60 mu M, and compound 4 exhibited moderate inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with an IC 50 value of 35.40 +/- 1.04 mu M.

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