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The plasma and tissue kinetics of sulfadiazine and its metabolite in Ictalurus punctatus after oral gavage at two temperatures

文献类型： 外文期刊

作者： Xu, Ning 1 ; Cheng, Bo 3 ; Yang, Yibin 1 ; Liu, Yongtao 1 ; Dong, Jing 1 ; Yang, Qiuhong 1 ; Zhou, Shun 1 ; Song, Yi 3 ; Ai, Xiaohui 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, 8 Wuda Park Rd 1, Wuhan 430223, Peoples R China

2.Hu Bei Prov Engn & Technol Res Ctr Aquat Prod Qual, Wuhan, Peoples R China

3.Chinese Acad Fishery Sci, Aquat Prod Qual & Stand Res Ctr, Beijing, Peoples R China

4.Chinese Acad Fishery Sci, 150 Qingta West Rd, Beijing 100141, Peoples R China

关键词： N-4-acetyl sulfadiazine; channel catfish; pharmacokinetics; sulfadiazine; temperature

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.3； 五年影响因子：1.4 ）

ISSN： 0140-7783

年卷期： 2023 年 46 卷 2 期

页码：

收录情况： SCI

摘要： A plasma and tissue kinetic study of sulfadiazine (SDZ) and its metabolite, N-4-acetyl sulfadiazine (ACT-SDZ), was characterized in channel catfish (Ictalurus punctatus) following a single oral dose of 50 mg/kg at 18 and 24 degrees C. Samples were collected at predetermined time points and determined by ultra-performance liquid chromatography. The classical one-compartmental method was used to estimate the pharmacokinetic parameters. Results showed that the changing of temperature was markedly influential on the kinetics of SDZ and ACT-SDZ in plasma and tissues. When the temperature was increased from 18 to 24 degrees C, the elimination half-life (K10_HF) of SDZ was decreased in gill, kidney, and muscle + skin, but increased in liver and plasma. The K10_HF of ACT-SDZ also had a decreased trend in gill, liver, and plasma but had comparable values in kidney and muscle + skin. The absorption half-life (K01_HF), time to peak concentration (T-max), and area under concentration-time curve (AUC(0-infinity)) of SDZ and ACT-SDZ all exhibited declined tendencies in plasma and tissues. The apparent volume of distribution (V_F) of SDZ in plasma was increased from 0.53 to 1.48 L/kg, and the apparent systemic total body clearance (Cl_F) was increased from 0.028 to 0.060 L/h/kg. In a word, K01_HF, T-max, and AUC(0-infinity) of SDZ and ACT-SDZ were decreased in plasma and tissues with the increase of temperature, whereas the V_F and Cl_F of SDZ were increased. Meanwhile, we calculated the percentage of time profile of SDZ concentration more than minimum inhibitory concentration to total time (%T > MIC) to guide clinical usage of SDZ. When the dosage interval was 24 h, the values of %T > MIC were all >90% in plasma and most tissues. Therefore, we recommend an oral dose of SDZ at 50 mg/kg once per 24 h at 18-24 degrees C against the fish pathogens with an MIC value of <= 6.4 mu g/mL.

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