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Metabolic Characteristics of Porcine LA-MRSA CC398 and CC9 Isolates from Germany and China via Biolog Phenotype MicroArray (TM)

文献类型： 外文期刊

作者： Krueger-Haker, Henrike 1 ; Ji, Xing 3 ; Bartel, Alexander 4 ; Fessler, Andrea T. 1 ; Hanke, Dennis 1 ; Jiang, Nansong 5 ; Tedin, Karsten 1 ; Maurischat, Sven 6 ; Wang, Yang 5 ; Wu, Congming 5 ; Schwarz, Stefan 1 ;

作者机构： 1.Free Univ Berlin, Inst Microbiol & Epizoot, Dept Vet Med, D-14163 Berlin, Germany

2.Free Univ Berlin, Vet Ctr Resistance Res TZR, D-14163 Berlin, Germany

3.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base Minist Sci Technol, Nanjing 210000, Peoples R China

4.Free Univ Berlin, Dept Vet Med, Inst Vet Epidmiol & Biostat, D-14163 Berlin, Germany

5.China Agr Univ, Coll Vet Med, Key Lab Anim Antimicrobial Resistance Surveillanc, MARA, Beijing 100193, Peoples R China

6.German Fed Inst Risk Assessment, Dept Biol Safety BfR, D-10589 Berlin, Germany

关键词： Staphylococcus aureus; metabolic properties; area under the curve (AUC); sparse partial least squares discriminant analysis (sPLS-DA); whole-genome sequencing (WGS)

期刊名称：MICROORGANISMS （ 影响因子：4.926； 五年影响因子：5.143 ）

ISSN：

年卷期： 2022 年 10 卷 11 期

页码：

收录情况： SCI

摘要： Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is an important zoonotic pathogen, often multi-resistant to antimicrobial agents. Among swine, LA-MRSA of clonal complex (CC) 398 dominates in Europe, Australia and the Americas, while LA-MRSA-CC9 is the main epidemic lineage in Asia. Here, we comparatively investigated the metabolic properties of rare and widespread porcine LA-MRSA isolates from Germany and China using Biolog Phenotype MicroArray technology to evaluate if metabolic variations could have played a role in the development of two different epidemic LA-MRSA clones in swine. Overall, we were able to characterize the isolates' metabolic profiles and show their tolerance to varying environmental conditions. Sparse partial least squares discriminant analysis (sPLS-DA) supported the detection of the most informative substrates and/or conditions that revealed metabolic differences between the LA-MRSA lineages. The Chinese LA-MRSA-CC9 isolates displayed unique characteristics, such as a consistently delayed onset of cellular respiration, and increased, reduced or absent usage of several nutrients. These possibly unfavorable metabolic properties might promote the ongoing gradual replacement of the current epidemic LA-MRSA-CC9 clone in China with the emerging LA-MRSA-CC398 lineage through livestock trade and occupational exposure. Due to the enhanced pathogenicity of the LA-MRSACC398 clone, the public health risk posed by LA-MRSA from swine might increase further.

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