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Fermented Cerasus humilis fruits protect against high-fat diet induced hyperlipidemia which is associated with alteration of gut microbiota

文献类型： 外文期刊

作者： Wang, Yu 1 ; Han, Chao 1 ; Cheng, Jinghe 1 ; Wang, Zhanjun 2 ; Liu, Lulu 1 ; Huang, Houyu 1 ; Liang, Qiuxia 1 ; Liu, Ruiying 1 ; Ran, Beibei 1 ; Li, Weidong 1 ;

作者机构： 1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China

2.Ningxia Acad Agr & Forestry Sci, Inst Desertificat Control, Yinchuan, Peoples R China

3.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China

关键词： Cerasus humilis fruit; fermentation; gut microbiota; hyperlipidemia

期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：4.125； 五年影响因子：4.096 ）

ISSN： 0022-5142

年卷期：

页码：

收录情况： SCI

摘要： BACKGROUNDHyperlipidemia is regarded as a public health matter, and its effective prevention and treatment are urgently required. However, the treatment of hyperlipidemia is still relatively scarce. RESULTSFermented Cerasus humilis fruit (FCHF) had higher total flavonoid, total phenolic, procyanidin, and organic and free amino acid content, and lower total sugar content, than non-fermented C. humilis fruit (NFCHF). Both FCHF and NFCHF treatment significantly prevent putting on weight. Furthermore, FCHF administration ameliorated hyperlipidemia and cholesterol over-accumulation. In addition, FCHF administration activated the antioxidase system and decreased the malondialdehyde content to relieve oxidative stress, and showed more efficaciously than NFCHF administration. FCHF treatments significantly reverse the fat deposition in high-fat diet rat liver. FCHF supplementation can relieve the dysbacteriosis induced by hyperlipidemia, and regulate the composition of rat gut microbiota by increasing the abundance of Prevotella and norank_f_Muribaculaceae. CONCLUSIONLactobacillus plantarum and Saccharomyces cerevisiae fermentation enhanced the antihyperlipidemic property of C. humilis fruits by promoting gut microbiota regulation. (c) 2022 Society of Chemical Industry.

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