您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Transcriptomics in Rare Minnow (Gobiocypris rarus) towards Attenuated and Virulent Grass Carp Reovirus Genotype II Infection

文献类型： 外文期刊

作者： Ma, Jie 1 ; Xu, Chen 1 ; Jiang, Nan 1 ; Meng, Yan 1 ; Zhou, Yong 1 ; Xue, Mingyang 1 ; Liu, Wenzhi 1 ; Li, Yiqun 1 ; Fan, Yuding 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China

2.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai 201306, Peoples R China

关键词： transcriptomics; grass carp reovirus; rare minnow; Gobiocypris rarus; spleen; liver

期刊名称：ANIMALS （ 2022影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2023 年 13 卷 11 期

页码：

收录情况： SCI

摘要： Grass carp reovirus genotype II (GCRV II) is the leading cause of death in grass carp. To investigate the involved molecular responses against the GCRV II infection, we performed comparative transcriptomic analysis in the spleen and liver of rare minnow injected with virulent and attenuated strains. Results showed that the virulent strain infection especially induced tissue-specific alteration and caused severe suppression of hemorrhage related pathways in spleen. Our finding provides new insights on the interactions between host and GCRV II. Grass carp reovirus genotype II (GCRV II) causes a variety of fish hemorrhagic disease, which seriously affects the sustainable development of grass carp aquaculture in China. Rare minnow (Gobiocypris rarus) is an ideal model fish to study the pathogenesis of GCRV II. To investigate the involved molecular responses against the GCRV II infection, we performed comparative transcriptomic analysis in the spleen and liver of rare minnow injected with virulent strain DY197 and attenuated strain QJ205. Results showed that the virulent DY197 strain induced more differently expressed genes (DEGs) than the attenuated QJ205 strain, and tissue-specific responses were induced. In the spleen, the attenuated and virulent strains induced different DEGs; the attenuated QJ205 infection activated steroid synthesis pathway that involved in membrane formation; however, virulent DY197 infection activated innate immunity and apoptosis related pathways while suppressing cell proliferation and migration related pathways that are important for damage tissue repair, as well as hemorrhage related pathways. In the liver, the attenuated and virulent strains infection induced similar DEGs; both strains infection activated immunity and apoptosis related pathways but suppressed metabolism-related pathways; virulent DY197 infection especially activated protein digestion and absorption-related pathways and suppressed steroid synthesis pathway. To conclude, virulent strain infection especially induced tissue-specific alterations and caused severe suppression of hemorrhage-related pathways in spleen. Our findings will contribute to better understanding of the interactions between host and GCRV II

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台