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Effect of Gentianella acuta (Michx.) Hulten against the arsenic-induced development hindrance of mouse oocytes

文献类型： 外文期刊

作者： Wang, Chunyu 1 ; Wang, Biao 3 ; Wei, Ying 1 ; Li, Shubin 4 ; Ren, Jingyu 5 ; Dai, Yanfeng 5 ; Liu, Gang 1 ;

作者机构： 1.Inner Mongolia Med Univ, Clin Med Res Ctr, Key Lab Med Cell Biol, Affiliated Hosp, Hohhot 010030, Inner Mongolia, Peoples R China

2.Inner Mongolia Univ Technol, Dept Environm Sci & Engn, Hohhot 010051, Inner Mongolia, Peoples R China

3.Inner Mongolia Acad Agr & Anim Husb Sci, Anim Husb Inst, Hohhot 010031, Inner Mongolia, Peoples R China

4.Inner Mongolia Peoples Hosp, Dept Geriatr Med Ctr, Hohhot 010010, Inner Mongolia, Peoples R China

5.Inner Mongolia Univ, Coll Life Sci, Hohhot 010021, Inner Mongolia, Peoples R China

关键词： Gentianella acuta; Arsenic; Oocytes; Redox regulation; H3K27me3

期刊名称：BIOMETALS （ 影响因子：3.5； 五年影响因子：3.3 ）

ISSN： 0966-0844

年卷期： 2024 年

页码：

收录情况： SCI

摘要： The current study was designed to investigate the alleviative effect of Gentianella acuta (Michx.) Hulten (G. acuta) against the sodium arsenite (NaAsO2)-induced development hindrance of mouse oocytes. For this purpose, the in vitro maturation (IVM) of mouse cumulus-oocyte complexes (COCs) was conducted in the presence of NaAsO2 and G. acuta, followed by the assessments of IVM efficiency including oocyte maturation, spindle organization, chromosome alignment, cytoskeleton assembly, cortical granule (CGs) dynamics, redox regulation, epigenetic modification, DNA damage, and apoptosis. Subsequently, the alleviative effect of G. acuta intervention on the fertilization impairments of NaAsO2-exposed oocytes was confirmed by the assessment of in vitro fertilization (IVF). The results showed that the G. acuta intervention effectively ameliorated the decreased maturation potentials and fertilization deficiency of NaAsO2-exposed oocytes but also significantly inhibited the DNA damages, apoptosis, and altered H3K27me3 expression level in the NaAsO2-exposed oocytes. The effective effects of G. acuta intervention against redox dysregulation including mitochondrial dysfunctions, accumulated reactive oxygen species (ROS) generation, glutathione (GSH) deficiency, and decreased adenosine triphosphate (ATP) further confirmed that the ameliorative effects of G. acuta intervention against the development hindrance of mouse oocytes were positively related to the antioxidant capacity of G. acuta. Evidenced by these abovementioned results, the present study provided fundamental bases for the ameliorative effect of G. acuta intervention against the meiotic defects caused by the NaAsO2 exposure, benefiting the future application potentials of G. acuta intervention in these nutritional and therapeutic research for attenuating the outcomes of arseniasis.

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