Dietary succinic acid mitigates adverse effects of starch high-starch diet in largemouth bass (Micropterus salmoides) through gut-liver axis modulation
文献类型： 外文期刊
作者： Liu, Yangyang 1 ; Cao, Manxia 1 ; Zhang, Jianmin 1 ; Wang, Xuan 3 ; Jiang, Ming 1 ; Huang, Feng 2 ; Cheng, Ke 1 ; Dong, Lixue 1 ; Peng, Di 1 ; Tian, Juan 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Key Lab Freshwater Biodivers Conservat, Minist Agr, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China
2.Wuhan Polytech Univ, Key Lab Anim Nutr & Feed Sci Hubei Prov, Wuhan 430023, Peoples R China
3.Ocean Univ China, Key Lab Mariculture, Minist Educ, Qingdao 266003, Peoples R China
关键词： Succinic acid; High-starch diet; Glucolipid metabolism; Enterohepatic health
期刊名称：FISH PHYSIOLOGY AND BIOCHEMISTRY （ 影响因子：2.5； 五年影响因子：3.1 ）
ISSN： 0920-1742
年卷期： 2025 年 51 卷 4 期
页码：
收录情况： SCI
摘要： A 10-week feeding trial was conducted to investigate the effects of succinic acid (SUA) supplementation in high-starch diets (HSD) on growth and enterohepatic health of largemouth bass (Micropterus salmoides; initial weight 11.96 +/- 0.71 g). Six isocaloric and isolipidic diets were formulated, comprising a standard diet containing 10% corn starch and 40% fish meal, an HSD with 15% corn starch and 36% fish meal, and HSDs supplemented with 0.5%, 1.0%, 1.5%, and 2.0% SUA. Compared to standard diet, HSD exhibited adverse effects including impaired feed utilization, growth retardation, diminished antioxidant capacity, and immune response, along with metabolic dysregulation and gut microbiota disturbances. Significant linear and quadratic dose-responses were detected for multiple parameters: feed conversion ratio, hepatosomatic index, viscerosomatic index, glycogen content, amylase and protease activities, and hepatic antioxidant status. The 0.5% SUA supplementation group demonstrated enhanced intestinal morphology, upregulated expression of tight junction proteins (ZO-1 and Claudin-4) and antiapoptotic Bcl2, increased abundance of beneficial microbiota and suppressed endoplasmic reticulum stress markers (GRP78, PERK, IRE1, ATF6, eIF2 alpha, and Chop alpha). Additionally, dietary 0.5% SUA upregulated hepatic anti-inflammatory mediators (Nrf2, TGF beta 1, and IL10), glycolytic genes (PK, PFKL2, and GK), beta-oxidation-related CPT1, antiapoptotic Bag, and glucose transporter GLUT2, while downregulating proinflammatory TNF alpha, gluconeogenic enzymes (PEPCK and G6Pase), lipogenic genes (ACC1 and FASN), and proapoptotic Bad. Broken-line regression analysis identified 0.46-0.50% as the optimal SUA inclusion level based on growth parameters. This study demonstrates that appropriate SUA supplementation alleviates HSD-induced oxidative stress, enhances intestinal barrier function, modulates gut microbiota, and maintains metabolic homeostasis, thereby improving starch utilization and growth performance.
- 相关文献
作者其他论文 更多>>
-
Effects of Temporary Rearing on the Muscle Flavor Quality of Chinemys reevesii
作者：Lu, Xiaorong;Yu, Yali;Dong, Lixue;Zhang, Lang;Mao, Tao;Zhou, Yuntao;He, Li;Lu, Xiaorong;He, Gang;Liu, Yun
关键词：
Chinemys reevesii -
The long-term effect of non-invasive sampling on the genetic diversity and growth performance of cultured Gymnocypris chilianensis (Cyprinidae) population: an evaluation based on 70 days
作者：Liu, Biyuan;Cheng, Qiqun;Peng, Di;Song, Dan;Liu, Biyuan;Song, Dan;Lou, Zhongyu;Qin, Yong
关键词：Non-invasive sampling; Gymnocypris chilianensis; molecular marker; Genetic diversity; growth performance
-
Mechanisms of hepatic dysfunction in Nile tilapia (Oreochromis niloticus) fed a high-fava bean (Vicia faba L.) diet
作者：Zhang, Xinyao;Zhang, Xinyao;Cheng, Ke;Dong, Lixue;Tian, Juan;Peng, Di;Zhang, Jianmin;Liu, Yangyang;Wen, Hua;Jiang, Ming;Zhu, Dexing;Li, Qingyong;Guo, Zhongbao;Luo, Yongju;Liu, Apeng
关键词：Tilapia; Fava bean; Muscle texture; Liver health; Metabolomics
-
Appropriate Fat Supplementation in High-Starch Diets Involved in the Modification of Fatty Acids Profile, Amino Acids Composition, and Antioxidant Capacity of Adult Nile Tilapia (Oreochromis niloticus) Muscle
作者：Zhang, Jianmin;Xie, Ningning;Jiang, Ming;Dong, Lixue;Wen, Hua;Tian, Juan
关键词：antioxidant capacity; fat level; flavor; high starch diet; nutritional value
-
Dietary Phaffia rhodozyma-Synthesized 3S, 3′S-Astaxanthin Promotes Body Coloration and Muscle Quality in Pacific White Shrimp Litopenaeus vannamei
作者：Zhang, Beili;Zhang, Chunyang;Xu, Jianing;Wang, Wenyi;Li, Chaoqun;Ma, Qinyuan;Zhang, Chengguo;Ma, Qinyuan;Tian, Juan
关键词：3S; 3 ' S-astaxanthin; body coloration;
Litopenaeus vannamei ; muscle quality; nutritional composition; texture -
Effects of lipid levels on growth performance and glucose and lipid metabolism of adult Nile tilapia ( Oreochromis niloticus) fed with high carbohydrate diets
作者：Xie, Ningning;Zhang, Jianmin;Jiang, Ming;Dong, Lixue;Lu, Xing;Wen, Hua;Tian, Juan;Meng, Xiaolin;Tian, Juan
关键词：Nile tilapia; High carbohydrate; Low lipid; Growth performance; Metabolic regulation
-
Effects of sodium butyrate on meat quality improvement and intestinal injury induced by high-level fava beans in Nile tilapia (Oreochromis niloticus)
作者：Qi, Haishen;Cheng, Ke;Dong, Lixue;Tian, Juan;Peng, Di;Wen, Hua;Liu, Mingdian;Jiang, Ming;Qi, Haishen;Yang, Ruibin;Guo, Zhongbao;Luo, Yongju
关键词：Nile tilapia; Fava bean; Sodium butyrate; Meat quality; Intestinal health
