Antiviral Activities of Carbazole Derivatives against Porcine Epidemic Diarrhea Virus In Vitro
文献类型： 外文期刊
作者： Chen, Zheng 1 ; Chen, Jinfeng 1 ; Wei, Xiaodong 1 ; Hua, Huiying 1 ; Hu, Ruiming 3 ; Ding, Nengshui 4 ; Zhang, Jinhua 1 ; Song, Deping 1 ; Ye, Yu 1 ; Tang, Yuxin 1 ; Ding, Zhen 1 ; Ke, Shaoyong 5 ;
作者机构： 1.Jiangxi Agr Univ, Coll Anim Sci & Technol, Dept Vet Prevent Med, Nanchang 330045, Jiangxi, Peoples R China
2.Jiangxi Agr Univ, Coll Anim Sci & Technol, Jiangxi Engn Res Ctr Anim Hlth Prod, Nanchang 330045, Jiangxi, Peoples R China
3.Jiangxi Agr Univ, Inst Anim Populat Hlth, Coll Anim Sci & Technol, Jiangxi Prov Key Lab Anim Hlth, Nanchang 330045, Jiangxi, Peoples R China
4.Jiangxi Agr Univ, State Key Lab Pig Genet Improvement & Prod Techno, Nanchang 330045, Jiangxi, Peoples R China
5.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China
关键词： antiviral drug; carbazole derivatives; porcine epidemic diarrhea virus
期刊名称：VIRUSES-BASEL （ 影响因子：5.818； 五年影响因子：5.811 ）
ISSN：
年卷期： 2021 年 13 卷 12 期
页码：
收录情况： SCI
摘要： Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, causes neonatal pig acute gastrointestinal infection with a characterization of severe diarrhea, vomiting, high morbidity, and high mortality, resulting in tremendous damages to the swine industry. Neither specific antiviral drugs nor effective vaccines are available, posing a high priority to screen antiviral drugs. The aim of this study is to investigate anti-PEDV effects of carbazole alkaloid derivatives. Eighteen carbazole derivatives (No.1 to No.18) were synthesized, and No.5, No.7, and No.18 were identified to markedly reduce the replication of enhanced green fluorescent protein (EGFP) inserted-PEDV, and the mRNA level of PEDV N. Flow cytometry assay, coupled with CCK8 assay, confirmed No.7 and No.18 carbazole derivatives displayed high inhibition effects with low cell toxicity. Furthermore, time course analysis indicated No.7 and No.18 carbazole derivatives exerted inhibition at the early stage of the viral life cycle. Collectively, the analysis underlines the benefit of carbazole derivatives as potential inhibitors of PEDV, and provides candidates for the development of novel therapeutic agents.
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