文献类型： 外文期刊

作者： Hong, Chun ¹ ; Li, Xinming ¹ ; Zhang, Kunli ² ; Huang, Qiuyan ¹ ; Li, Baohong ¹ ; Xin, Haiyun ¹ ; Hu, Bin ¹ ; Meng, Fanming ¹ ; Zhu, Xiangxing ⁴ ; Tang, Dongsheng ⁴ ; Hu, Chuanhuo ³ ; Tao, Chenyu ⁶ ; Li, Jianhao ¹ ; Cao, Yang ⁷ ; Wang, Hai ⁸ ; Deng, Bo ⁹ ; Wang, Sutian ¹ ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Swine & Poultry Breeding Ind, Guangdong Key Lab Anim Breeding & Nutr, Guangzhou, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Hlth,Minist Agr & Rural Affairs, Guangdong Prov Key Lab Livestock Dis Prevent Guang, Sci Observat & Expt Stn Vet Drugs & Diagnost Tech, Guangzhou, Guangdong, Peoples R China

3.Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China

4.Foshan Univ, Sch Life Sci & Engn, Guangdong Prov Key Lab Anim Mol Design & Precise, Foshan, Peoples R China

5.Guangxi Univ, Guangxi Key Lab Anim Reprod Breeding & Dis Control, Nanning, Peoples R China

6.Hebei Agr Univ, Coll Anim Sci & Technol, Baoding, Hebei, Peoples R China

7.Jilin Acad Agr Sci, Branch Anim Husb, Gongzhuling, Peoples R China

8.Chinese Acad Sci, HKU Guangdong Hong Kong Stem Cell, Guangzhou Inst Biomed & Hlth,Guangdong Hong Kong S, Key Lab Regenerat Biol,Guangzhou Inst Biomed & Hlt, Guangzhou, Peoples R China

9.Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Div Nephrol, Shanghai, Peoples R China

10.Guangdong Lab Lingnan Modern Agr, Maoming Branch, Maoming, Peoples R China

关键词： adipogenesis; autophagy; inflammation; oxidative stress; immune responses

期刊名称：FRONTIERS IN ENDOCRINOLOGY （ 影响因子：3.9； 五年影响因子：4.9 ）

ISSN： 1664-2392

年卷期： 2024 年 15 卷

页码：

收录情况： SCI

摘要： Adipose tissue, an indispensable organ, fulfils the pivotal role of energy storage and metabolism and is instrumental in maintaining the dynamic equilibrium of energy and health of the organism. Adipocyte hypertrophy and adipocyte hyperplasia (adipogenesis) are the two primary mechanisms of fat deposition. Mature adipocytes are obtained by differentiating mesenchymal stem cells into preadipocytes and redifferentiation. However, the mechanisms orchestrating adipogenesis remain unclear. Autophagy, an alternative cell death pathway that sustains intracellular energy homeostasis through the degradation of cellular components, is implicated in regulating adipogenesis. Furthermore, adipose tissue functions as an endocrine organ, producing various cytokines, and certain inflammatory factors, in turn, modulate autophagy and adipogenesis. Additionally, autophagy influences intracellular redox homeostasis by regulating reactive oxygen species, which play pivotal roles in adipogenesis. There is a growing interest in exploring the involvement of autophagy, inflammation, and oxidative stress in adipogenesis. The present manuscript reviews the impact of autophagy, oxidative stress, and inflammation on the regulation of adipogenesis and, for the first time, discusses their interactions during adipogenesis. An integrated analysis of the role of autophagy, inflammation and oxidative stress will contribute to elucidating the mechanisms of adipogenesis and expediting the exploration of molecular targets for treating obesity-related metabolic disorders.