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Deletion of miR-M8 and miR-M13 eliminates the bursa atrophy induced by Marek's disease virus infection

文献类型： 外文期刊

作者： Bai, Yilin 1 ; Liao, Yifei 4 ; Yang, Shuaikang 2 ; Jin, Jiaxin 2 ; Lu, Wenlong 2 ; Teng, Man 5 ; Luo, Jun 5 ; Zhang, Gaiping 2 ; Sun, Aijun 2 ; Zhuang, Guoqing 2 ;

作者机构： 1.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China

2.Henan Agr Univ, Coll Vet Med, Zhengzhou 450002, Henan, Peoples R China

3.Henan Agr Univ, Coll Vet Med, Int Joint Res Ctr Natl Anim Immunol, Zhengzhou 450002, Henan, Peoples R China

4.Harvard Med Sch, Div Infect Dis, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA

5.Henan Acad Agr Sci, Key Lab Anim Immunol, Minist Agr & Rural Affairs, Zhengzhou 450002, Henan, Peoples R China

6.Henan Acad Agr Sci, Henan Prov Key Lab Anim Immunol, Zhengzhou 450002, Henan, Peoples R China

7.Henan Acad Agr Sci, UK China Ctr Excellence Res Avian Dis, Zhengzhou 450002, Henan, Peoples R China

8.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China

关键词： Marek's disease virus; MicroRNA; MiR-M8; MiR-M13; Replication; Pathogenesis

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.246； 五年影响因子：3.565 ）

ISSN： 0378-1135

年卷期： 2022 年 268 卷

页码：

收录情况： SCI

摘要： Marek's disease (MD) is a neoplastic disease of chickens caused by an avian alphaherpesvirus, Marek's disease virus (MDV, also known as Gallid alphaherpesvirus 2 [GaHV2]). A total of 14 microRNA (miRNA) precursors and 26 mature miRNAs have been identified in MDV genome, which were grouped in three distinct clusters. In recent years, our studies revealed the role of MDV encoded cluster 3 miRNAs (or miR-M8-M10) and the specific function of its three members, miR-M6, miR-M7 and miR-M10, in regulating MDV replication and pathogenesis. In this study, we characterized the unique function of the other two members, miR-M8 and miR-M13, in cluster 3 miRNAs. Our results show that miR-M8 and miR-M13 are not important for MDV plaque formation and genome replication in vitro. Animal experiment results show that deletion of miR-M8-5p and miR-M13-5p eliminates the bursa atrophy, but not thymus atrophy, of MDV inoculated chickens. In addition, we found that the survival curve and MD incidences were not affected by disruption of miR-M8 and miR-M13. Taken together, this study uncovers the unique role of miR-M8 and miR-M13 in MDV replication and pathogenesis, which filled the gap in the research of MDV encoded miRNAs.

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