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Effect of Agaricus bisporus Polysaccharides (ABPs) on anti-CCV immune response of channel catfish

文献类型： 外文期刊

作者： Yang, Yibin 1 ; Zhu, Xia 1 ; Liu, Yongtao 1 ; Xu, Ning 1 ; Kong, Weiguang 2 ; Ai, Xiaohui 1 ; Zhang, Hongyu 3 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China

2.Inst Hydrobiol, Chinese Acad Sci, Key Lab Breeding Biotechnol & Sustainable Aquacult, Wuhan 430072, Peoples R China

3.Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing 100141, Peoples R China

关键词： Ictalurus punctatus; Agaricus bisporus polysaccharides; Inflammatory reaction; Channel catfish virus

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2023 年 141 卷

页码：

收录情况： SCI

摘要： Herein, the effects of Agaricus bisporus Polysaccharides (ABPs) on anti-channel catfish virus (CCV) infections to promote their application in channel catfish culture were explored. Transcriptome and metabolome analyses were conducted on the spleen of a CCV-infected channel catfish model fed with or without ABPs. CCV infections upregulated many immune and apoptosis-related genes, such as IL-6, IFN-alpha 3, IFN-gamma 1, IL-26, Casp3, Casp8, and IL -10, and activated specific immunity mediated by B cells. However, after adding ABPs, the expression of inflammation-related genes decreased in CCV-infected channel catfish, and the inflammatory inhibitors NLRC3 were upregulated. Meanwhile, the expression of apoptosis-related genes was reduced, indicating that ABPs can more rapidly and strongly enhance the immunity of channel catfish to resist viral infection. Moreover, the metabonomic analysis showed that channel catfish had a high energy requirement during CCV infection, and ABPs could enhance the immune function of channel catfish. In conclusion, ABPs can enhance the antiviral ability of channel catfish by enhancing immune response and regulating inflammation. Thus, these findings provided new insights into the antiviral response effects of ABPs, which might support their application in aquaculture.

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