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Screening and Identification of a Streptomyces Strain with Quorum-Sensing Inhibitory Activity and Effect of the Crude Extracts on Virulence Factors of Pseudomonas aeruginosa

文献类型： 外文期刊

作者： Zhang, Zhidong 1 ; Sun, Yang 3 ; Yi, Yuanyang 1 ; Bai, Xiaoyu 1 ; Zhu, Liying 4 ; Zhu, Jing 1 ; Gu, Meiying 1 ; Zhu, Yanlei 2 ; Jiang, Ling 3 ;

作者机构： 1.Xinjiang Acad Agr Sci, Inst Microbiol, Xinjiang Key Lab Special Environm Microbiol, Urumqi 830091, Peoples R China

2.Xinjiang Normal Univ, Coll Life Sci, Urumqi 830054, Peoples R China

3.Nanjing Tech Univ, Coll Food Sci & Light Ind, Nanjing 211816, Peoples R China

4.Nanjing Tech Univ, Coll Chem & Mol Engn, Nanjing 211816, Peoples R China

关键词： quorum-sensing inhibitors; Actinomycete; Pseudomonas aeruginosa; virulence factors

期刊名称：MICROORGANISMS （ 影响因子：4.5； 五年影响因子：4.8 ）

ISSN：

年卷期： 2023 年 11 卷 8 期

页码：

收录情况： SCI

摘要： Quorum-sensing (QS) is involved in numerous physiological processes in bacteria, such as biofilm formation, sporulation, and virulence formation. Therefore, the search for new quorum-sensing inhibitors (QSI) is a promising strategy that opens up a new perspective for controlling QS-mediated bacterial pathogens. To explore new QSIs, a strain named Streptomyces sp. D67 with QS inhibitory activity was isolated from the soil of the arid zone around the Kumutag Desert in Xinjiang. Phylogenetic analyses demonstrated that strain D67 shared the highest similarity with Streptomyces ardesiacus NBRC 15402T (98.39%), which indicated it represented a potential novel species in the Streptomyces genus. The fermentation crude extracts of strain D67 can effectively reduce the violacein production produced by Chromobacterium violaceum CV026 and the swarming and swimming abilities of Pseudomonas aeruginosa. It also has significant inhibitory activity on the production of virulence factors such as biofilm, pyocyanin, and rhamnolipids of P. aeruginosa in a significant concentration-dependent manner, but not on protease activity. A total of 618 compounds were identified from the fermentation crude extracts of strain D67 by LC-MS, and 19 compounds with significant QS inhibitory activity were observed. Overall, the strain with QS inhibitory activity was screened from Kumutag Desert in Xinjiang for the first time, which provided a basis for further research and development of new QSI.

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