Acetylferulic paeonol ester: A new feed additive reduces lipid accumulation in the liver of Nile tilapia (Oreochromis niloticus) by modulating lipid and glucose metabolism
文献类型： 外文期刊
作者： Yu, Lijuan 1 ; Tian, Juan 1 ; Zhang, Chenxi 2 ; Xue, Zhiyong 2 ; Lu, Xing 1 ; Wen, Hua 1 ; Jiang, Ming 1 ; Wu, Fan 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Aquat Anim Nutr & Feed Div, Wuhan 430223, Peoples R China
2.Wuhan Text Univ, Coll Chem & Chem Engn, Hubei Key Lab Biomass Fibers & Eco Dyeing & Finish, Wuhan 430073, Peoples R China
关键词： Growth performance; Hepatic lipid accumulation; Lipid metabolism; Glucose metabolism; Tilapia
期刊名称：AQUACULTURE （ 影响因子：5.135； 五年影响因子：5.125 ）
ISSN： 0044-8486
年卷期： 2022 年 561 卷
页码：
收录情况： SCI
摘要： A 53-day feeding trial was conducted to investigate the effects of dietary acetylferulic paeonol ester (APE) levels on the growth performance, body composition, serum biochemical indicators and lipid and glucose metabolism of of Nile tilapia, Oreochromis niloticus. The results showed that 100 and 200 mg kg-1 APE significantly increased the weight gain (WG), while 200-3200 mg kg � 1 APE significantly decreased the crude lipid content of the liver. The supplementation of APE affected the serum biochemistry parameters associated with lipid and glucose metabolism. The liver transcriptome analysis revealed that the genes (such as hadhb, acads, acadl, acaa2, cpt1) related to fatty acid oxidation and degradation were significantly up-regulated, whereas the genes related to fatty acid biosynthesis (such as acaca, fasn, elovl5, acsl3a, scd, fads2) were significantly down-regulated by 200 mg kg � 1 APE. PPAR (peroxisome proliferator-activated receptor) and AMPK (Adenosine 5 '-monophosphate (AMP)activated protein kinase) signaling pathways were significantly enriched at 200 mg kg � 1 APE for differentially expressed genes (DEGs). The qPCR results showed an excellent agreement on those of RNA-seq for both up- and down-regulated genes (a total of seventeen genes selected for validation). Furthermore, 200 mg kg � 1 APE influenced hepatic glucose and lipid metabolism of tilapia at the enzymatic level and the mRNA level (genes included acads, acaa2, acadl, cpt1ab, ecil, fabp1b.l, hadhb, pcxb,cyp24, tktb, fads2, rgn, scd). Thus, APE reduced lipid accumulation in the liver of tilapia by modulating lipid and glucose metabolism.
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