Photosensitizer-based small molecule theranostic agents for tumor-targeted monitoring and phototherapy
文献类型： 外文期刊
作者： Gao, Jiake 1 ; Jiang, Hongfei 1 ; Chen, Pengwei 2 ; Zhang, Renshuai 1 ; Liu, Ning 1 ;
作者机构： 1.Qingdao Univ, Affiliated Hosp, Qingdao 266071, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Peoples R China
关键词： Theranostic; Photosensitizer; Phototherapy; Tumor -targeted imaging; Drug design
期刊名称：BIOORGANIC CHEMISTRY （ 影响因子：5.1； 五年影响因子：5.3 ）
ISSN： 0045-2068
年卷期： 2023 年 136 卷
页码：
收录情况： SCI
摘要： Small molecule theranostic agents for tumor treatment exhibited triadic properties in tumor targeting, imaging, and therapy, which have attracted increasing attention as a potential complement for, or improved to, classical small molecule antitumor drugs. Photosensitizer have dual functions of imaging and phototherapy, and have been widely used in the construction of small molecule theranostic agents over the last decade. In this review, we summarized representative agents that have been studied in the field of small molecule theranostic agents based on photosensitizer in the last decade, and highlighted their characteristics and application in tumor-targeted monitoring and phototherapy. The challenges and future perspectives of photosensitizers in building small molecule theranostic agents for diagnosis and therapy of tumors were also discussed.
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