Multifunctional small-molecule theranostic agents for tumor-specific imaging and targeted chemotherapy
文献类型： 外文期刊
作者： Zhang, Renshuai 1 ; Hao, Li 2 ; Chen, Pengwei 4 ; Zhang, Gang 1 ; Liu, Ning 1 ;
作者机构： 1.Qingdao Univ, Affiliated Hosp, Qingdao 266071, Peoples R China
2.Shandong First Med Univ, Affiliated Hosp 1, Dept Gerontol, Jinan 528051, Peoples R China
3.Shandong Prov Qianfoshan Hosp, Jinan 528051, Peoples R China
4.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab ReseCarch & Dev Nat Prod Li Folk Me, Haikou 571101, Peoples R China
关键词： Theranostics; Imaging; Chemotherapy; Multifunctional small molecules
期刊名称：BIOORGANIC CHEMISTRY （ 影响因子：5.1； 五年影响因子：5.3 ）
ISSN： 0045-2068
年卷期： 2023 年 137 卷
页码：
收录情况： SCI
摘要： Cancer is one of the leading causes of death worldwide. Although great progress has been achieved in cancer diagnosis and treatment, novel therapies are still urgently needed to increase the efficacy and reduce the side effects of conventional therapies. Personalized medicine involves administering patients drugs that are specific to the characteristics of their tumors, and has significantly reduced side effects and increased overall survival rates. Multifunctional theranostic drugs are designed to combine diagnostic and therapeutic functions into a single molecule, which reduces the number of drugs administered to patients and increases patient compliance, and have shown great potential in propelling personalized medicine. This review focuses on multifunctional smallmolecule theranostic agents for tumor-specific imaging and targeted chemotherapy, with a particular emphasis placed on highlighting design strategies and application in vitro or in vivo. The challenges and future perspectives of multifunctional small molecules are also discussed.
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